Cognitive Impairment: An Increasingly Important Complication of Type 2 Diabetes
Cognitive Impairment: An Increasingly Important Complication of Type 2 Diabetes
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DOI：
10.1093/aje/kwn228
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发表时间：
2008-11-15
影响因子：
5
通讯作者：
Launer, Lenore J.
中科院分区：
文献类型：
--
作者：
Saczynski, Jane S.;Jonsdottir, Maria K.;Launer, Lenore J.
2型糖尿病患者患认知功能障碍的风险增加。关于哪些认知能力受到影响以及未确诊的糖尿病和空腹血糖受损与认知能力的关系，人们知之甚少。作者使用来自1,917名非痴呆男性和女性（平均年龄= 76岁）的数据探索了这个问题，这些数据来自基于人口的年龄，基因/环境易感性-雷克雅未克研究（2002-2006）。血糖状态组包括确诊糖尿病（自我报告糖尿病或糖尿病药物使用; n = 163（8.5%）），未确诊糖尿病（空腹血糖≥ 7.0 mmol/L，未确诊糖尿病; n = 55（2.9%））和空腹血糖受损（空腹血糖5.6-6.9 mmol/L; n = 744（38.8%））。复合材料的记忆，处理速度（PS）和执行功能的神经心理电池。采用线性回归研究血糖组之间认知能力的横截面差异，调整人口统计学和健康因素。诊断为糖尿病的患者PS比血糖正常者慢（β = -0.12; P < 0.05）;糖尿病病程≥ 15年与PS和执行功能显著较差相关。未确诊的糖尿病患者PS较慢（β = -0.22; P < 0.01），记忆能力较差（β = -0.22; P < 0.05）。2型糖尿病患者的认知能力比血糖正常者差，特别是在PS中。那些未确诊的糖尿病患者的认知能力最低。
Persons with type 2 diabetes are at increased risk of cognitive dysfunction. Less is known about which cognitive abilities are affected and how undiagnosed diabetes and impaired fasting glucose relate to cognitive performance. The authors explored this question using data from 1,917 nondemented men and women (average age = 76 years) in the population-based Age, Gene/Environment Susceptibility-Reykjavik Study (2002-2006). Glycemic status groups included diagnosed diabetes (self-reported diabetes or diabetic medication use; n = 163 (8.5%)), undiagnosed diabetes (fasting blood glucose >= 7.0 mmol/L without diagnosed diabetes; n = 55 (2.9%)), and impaired fasting glucose (fasting blood glucose 5.6-6.9 mmol/L; n = 744 (38.8%)). Composites of memory, processing speed (PS), and executive function were constructed from a neuropsychological battery. Linear regression was used to investigate cross-sectional differences in cognitive performance between glycemic groups, adjusted for demographic and health factors. Persons with diagnosed diabetes had slower PS than normoglycemics (beta = -0.12; P < 0.05); diabetes duration of >= 15 years was associated with significantly poorer PS and executive function. Undiagnosed diabetics had slower PS (beta = -0.22; P < 0.01) and poorer memory performance (beta = -0.22; P < 0.05). Persons with type 2 diabetes have poorer cognitive performance than normoglycemics, particularly in PS. Those with undiagnosed diabetes have the lowest cognitive performance.