EFFECT OF BODY ORIENTATION ON REGIONAL LUNG EXPANSION - A COMPUTED TOMOGRAPHIC APPROACH
EFFECT OF BODY ORIENTATION ON REGIONAL LUNG EXPANSION - A COMPUTED TOMOGRAPHIC APPROACH
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DOI：
10.1152/jappl.1985.59.2.468
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
HOFFMAN, EA
中科院分区：
文献类型：
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作者：
HOFFMAN, EA
动态空间重建器 (DSR) 用于研究体内肺几何形状和功能。通过用已知空气含量的土豆片和乒乓球替换 3 只狗的肺，并在 DSR 中扫描这些真实的模型，肺密度的准确度估计在 7% 以内，并证明了高 (.+-. 3%) 内部一致性（狗内的相对密度）。根据麻醉狗的 DSR 体积成像计算得出的肺总空气含量 (y) 的变化与已知的充气步骤 (x) 相匹配，在 7% 范围内 [范围为 1-7%，平均值为 3 .+-。 0.5%（SE）]。在仰卧位的功能残气量 (FRC) 下，沿腹背侧方向测量肺空气含量百分比下降的梯度（y = 3.29% 空气含量/cm 肺高度 + 46.48% 空气含量；r = 0.90）。肺充气时区域肺空气含量的变化在相关肺区域最大。当狗处于俯卧姿势时，FRC 的区域肺空气含量沿腹背方向大致均匀，为 66.+-。 0.6%（SE）。在处于左侧或右侧身体姿势的狗的等重平面内测量的肺空气含量的腹背侧梯度表明，肺空气含量的区域差异不能仅仅根据对肺的直接重力作用来解释。建议纵隔内容物的胸腔内位置在确定这些肺空气含量分布中可能发挥重要作用。
The Dynamic Spatial Reconstructor (DSR) was used to study in vivo lung geometry and function. By replacing the lungs of 3 dogs with potato flakes and ping-pong balls of known air content and scanning these realistic phantoms in the DSR accuracy of lung density was estimated to be within 7% and a high (.+-. 3%) internal consistency (relative density within dogs) was demonstrated. Change in total lung air content (y) as calculated from DSR volume imaging of anesthetized dogs matched the known inflation steps (x) to within 7% [range was 1-7% with a mean of 3 .+-. 0.5% (SE)]. A gradient of decreasing percent lung air content was measured in the ventral-dorsal direction at functional residual capacity (FRC) in the supine body posture (y = 3.29% air content/cm lung height + 46.48% air content; r = 0.90). Regional lung air content change with lung inflation was greatest in the dependent lung regions. Regional lung air content at FRC was approximately uniform along the ventral dorsal direction with the dog in the prone posture and was 66 .+-. 0.6% (SE). Ventral-dorsal gradients in lung air content measured within an isogravimetric plane of the dogs in the left or right lateral body posture suggest that regional differences in lung air content cannot be explained solely on the basis of a direct gravitational effect on the lung. A possible major role of the intrathoracic position of the mediastinal contents in determining these lung air content distributions is suggested.