MORPHOREGULATORY MOLECULES
MORPHOREGULATORY MOLECULES
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DOI：
10.1021/bi00410a001
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发表时间：
1988-05-17
期刊：
影响因子：
2.9
通讯作者：
EDELMAN, GM
中科院分区：
文献类型：
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作者：
EDELMAN, GM
(Sperry，1963)，粘着是一个空间和时间上的动态过程，至少由三个不同的分子家族在一系列阶段中调节[参见Edelman和Thiery(1985)]。它受细胞控制，是地点的函数，在空间尺度的一端影响基因表达，在另一端影响形态发生。黏附是后生动物生命进化中的重要中介事件，在现代复杂动物中，它在发育和变态以及骨修复和再生等现象中起着核心作用。自从Holftreter(1948a，b)关于胚胎组织在体外解离后重新结合的开创性研究以来，黏附的重要性已经得到了很好的认识。但由于细胞黏附的广泛影响和多种背景，直到最近才很难将其生化基础与
(Sperry, 1963), adhesion is a spatially and temporally dynamic process mediated in a series of stages by at least three different families of molecules [see Edelman and Thiery (1985)]. It is under cellular control as a function of place, affecting gene expression at one end of the spatial scale and morphogenesis at the other. Adhesion was an essential mediating event in the evolution of metazoan life, and in present day complex animals, it plays a central role in development andmeta-morphosis, as well as in phenomena such as bone repair and regeneration.The developmental importance of adhesion has been par-ticularly well appreciated since the pioneering studies of Holftreter (1948a, b) on reassociation in vitro of embryonic tissues after dissociation. But because of the wide-ranging effects and multiple contexts of cell adhesion, it has been difficult until recently to relate its biochemical bases to the