PirB restricts ocular-dominance plasticity in visual cortex
PirB restricts ocular-dominance plasticity in visual cortex
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DOI：
10.1126/science.1128232
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发表时间：
2006-09-22
期刊：
影响因子：
56.9
通讯作者：
Shatz, Carla J.
中科院分区：
文献类型：
--
作者：
Syken, Josh;GrandPre, Tadzia;Shatz, Carla J.
经验可以改变突触连接在整个生命，但可塑性的程度目前在每个年龄是由机制，仍然在很大程度上未知的调节。在这里，我们证明了配对免疫球蛋白样受体B（Pir B），主要组织相容性复合物I类（MHCI）受体，在整个大脑的神经元亚群中表达。神经元PirB蛋白与突触相关，并与磷酸酶Shp-1和Shp-2形成复合物。可溶性PirB融合蛋白以MHCI依赖性方式与皮质神经元结合。在缺乏功能性PirB的突变小鼠中，皮质眼优势可塑性在所有年龄段都更强大。因此，MHCI受体在中枢神经系统神经元中表达，并在整个生命中起到限制视觉皮层中经验依赖性可塑性的程度的作用。PirB也在中枢神经系统的许多其他区域中表达，这表明它可能广泛地起稳定神经回路的作用。
Experience can alter synaptic connectivity throughout life, but the degree of plasticity present at each age is regulated by mechanisms that remain largely unknown. Here, we demonstrate that Paired-immunoglobulin-like receptor B (PirB), a major histocompatibility complex class I (MHCI) receptor, is expressed in subsets of neurons throughout the brain. Neuronal PirB protein is associated with synapses and forms complexes with the phosphatases Shp-1 and Shp-2. Soluble PirB fusion protein binds to cortical neurons in an MHCI-dependent manner. In mutant mice lacking functional PirB, cortical ocular-dominance plasticity is more robust at all ages. Thus, an MHCI receptor is expressed in central nervous system neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life. PirB is also expressed in many other regions of the central nervous system, suggesting that it may function broadly to stabilize neural circuits.