P2-27 Does social disadvantage in earlier childhood predispose to onset of limiting longterm illness (LLTI)/disability in later childhood? A population based study using the UK ONS Longitudinal Study (ONSLS)
P2-27 Does social disadvantage in earlier childhood predispose to onset of limiting longterm illness (LLTI)/disability in later childhood? A population based study using the UK ONS Longitudinal Study (ONSLS)
复制标题
P2-27 儿童早期的社会劣势是否容易导致儿童后期出现限制性长期疾病（LLTI）/残疾？
DOI：
10.1136/jech.2011.142976h.63
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发表时间：
2011
影响因子：
6.3
通讯作者：
Blackburn C
中科院分区：
文献类型：
--
作者：
Blackburn C
关于与儿童残疾相关的因素的预测因子和时间顺序缺乏经验证据。目的探讨儿童期早期社会劣势与儿童期后期LLTI/D发病的关系。方法确定在1981年至1991年英国人口普查期间出生的儿童，这些儿童成为了2001年人口普查的成员。提取1991年无LLTI/D但2001年有LLTI/D的儿童（指数）和两次均无LLTI/D的儿童（比较）的数据。构建了1991年社会劣势指数（SDI）。Logistic回归模型拟合LLTI/D，以SDI作为自变量，对年龄、性别、单亲父母和种族进行调整。结果在1981年至1991年期间，有6万多名儿童成为人口普查的成员，并参加了1991年和2001年的人口普查。指标组和对照组资料完整的52438例。在双变量分析中，社会劣势、年龄、性别和单身父母与指数组的LLTI/D发病显著相关，但与种族无关。校正混杂因素后，指数组的SDI与LLTI/D发病呈分级相关性(最不利OR=2.12 (1.77, 2.54)；在两个领域处于劣势OR=1.45 (1.20, 1.75)；OR=1.14(0.94, 1.40))。结论幼儿期社会劣势是儿童后期和青少年期LLTI/D发展的易感因素。社会劣势可能是儿童LLTI/D的原因和结果。
IntroductionThere is a lack of empirical evidence on the predictors and temporal ordering of factors associated with child disability.ObjectiveTo examine the relationship between social disadvantage in earlier childhood and the onset of LLTI/D in later childhood in the UK ONSLS.MethodsChildren born between the 1981 and 1991 UK censuses who became ONSLS members and were present at the 2001 census were identified. Data were extracted on those children who didn9t have LLTI/D in 1991 but did in 2001 (index) and those with no LLTI/D on either occasion (comparison). A social disadvantage index (SDI) was constructed for 1991. Logistic regression models were fitted on LLTI/D with the SDI as the independent variable of interest adjusted for age, gender, lone parenthood, and ethnicity.Results60 000+ children became ONSLS members between 1981 and 1991 and were present at the 1991 and 2001 censuses. 52 438 in the index and comparison groups had complete data. In bivariate analysis, social disadvantage, age, gender and lone parenthood but not ethnicity were significantly associated with the onset of LLTI/D in the index group. After adjustment for confounding, the SDI showed a finely graded association with onset of LLTI/D in the index group (most disadvantaged OR=2.12 (1.77, 2.54); disadvantaged in two domains OR=1.45 (1.20, 1.75); disadvantaged in one domain OR=1.14 (0.94, 1.40)).ConclusionsSocial disadvantage in earlier childhood as a predisposing factor for the development of LLTI/D in later childhood and adolescence. Social disadvantage may be both cause and consequence of childhood LLTI/D.