Sex hormones and the young brain: are we ready to embrace neuroprotective strategies?
Sex hormones and the young brain: are we ready to embrace neuroprotective strategies?
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性激素和年轻的大脑：我们准备好接受神经保护策略了吗？
DOI：
10.1016/j.bja.2021.10.032
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发表时间：
2022
影响因子：
9.8
通讯作者：
Jevtovic-Todorovic,Vesna
中科院分区：
文献类型：
--
作者：
Jevtovic-Todorovic,Vesna
越来越多的动物和临床数据继续表明，全身麻醉对非常年轻的大脑有潜在的危害。当我们试图了解导致这一令人担忧的现象的机制时，我们必须考虑保护策略的价值，即在使用当前可用的全身麻醉剂的同时，避免组织病理改变和行为和认知发展的长期损害。Wali和他的同事报告说，孕激素黄体酮是一种很有前途的“安全”剂，可以改善七氟醚（一种常用的吸入麻醉剂）引起的全身炎症，同时防止认知障碍和焦虑表型的发展。
Growing animal and clinical data continue to point to general anaesthetics as being potentially detrimental to the very young brain. While we are trying to understand the mechanisms responsible for this worrisome phenomenon, we must consider the value of protective strategies that would enable use of currently available general anaesthetics while avoiding histopathological changes and long-lasting impairment in behavioural and cognitive development. Wali and colleagues1report that the gestational hormone progesterone is a promising ‘safening’ agent that ameliorates systemic inflammation caused by sevoflurane, a commonly used inhaled anaesthetic, while preventing development of cognitive impairment and an anxious phenotype.