Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy
Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy
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通过 Catellani 策略合成苯并稠合二氧杂环支架
DOI：
10.1021/acs.orglett.9b03228
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Zhou Qianghui
中科院分区：
文献类型：
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作者：
Wu Chenggui;Yang Xinjun;Shang Yong;Cheng Hong-Gang;Yan Wei;Zhou Qianghui
报道了一种用于制备独特的苯并二恶双环支架的模块化策略，该支架包括芳基碘化物、环氧化物和末端炔烃的Catellani反应和缺氧环化。这是一种温和的、可扩展的、化学选择性的、原子经济的协议，与各种官能化的芳基碘、环氧化物和末端炔兼容。这种方法能够快速有效地从原料化学品中建立分子的复杂性，在有机合成中将有广泛的应用前景。
Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and anoxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the molecular complexity rapidly and efficiently from feedstock chemicals, this method will have wide applications in organic synthesis.