Catalyst-free aerobic radical cascade reactions of o-vinylphenylisocyanides with thiols to access 2-thio-substituted quinolines
Catalyst-free aerobic radical cascade reactions of o-vinylphenylisocyanides with thiols to access 2-thio-substituted quinolines
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DOI：
10.1039/d2qo01371a
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发表时间：
2022
影响因子：
5.4
通讯作者：
Xianxiu Xu
中科院分区：
文献类型：
--
作者：
Jin Wang;Haitao Liu;Yaohui Liu;Wanting Hao;Yingqi Yang;Yanan Sun;Xianxiu Xu
We herein report an efficient and green aerobic radical cascade reaction of o-vinylphenylisocyanides with thiols to access a broad range of 2-thio-substituted quinolines without the need for additional catalysts or oxidants. Mechanistic investigations suggested that this reaction was initiated by a thiyl radical generated under aerobic conditions to form thioimidoyl radicals, followed by radical annulation with a vinyl substituent.
