A Rathke's cleft cyst located entirely in the anterior pituitary lobe.
A Rathke's cleft cyst located entirely in the anterior pituitary lobe.
复制标题
拉特克裂囊肿完全位于垂体前叶。
DOI：
10.1007/s00701-013-1666-4
复制
发表时间：
2013
期刊：
影响因子：
2.4
通讯作者：
Kurisu K.
中科院分区：
文献类型：
--
作者：
Kinoshita Y;Tominaga A;Usui S;Kurisu K.
亲爱的编辑，Rathke的裂囊(RCC)通常起源于Rathke的口袋残留物，起源于原始的口腔。根据Rathke裂的胚胎学，有可能解释RCC的位置，即使是在非常罕见的区域，如完全在鞍上区[4，9]，蝶窦[6]和蝶骨[3]。另一方面，胚胎学理论不能解释位于垂体前叶的肾细胞癌的起源。我们在此报告首例完全位于垂体前叶的肾细胞癌，并假设此肾细胞癌的起源可能是由于白血病抑制因子(LIF)的表达，导致上皮细胞从Rathke‘s裂隙迁移到Rathke’s囊前壁。入院时的神经学检查显示没有异常。入院时内分泌学检查均在正常范围内。MRI在T1加权像(图1a)和T2加权像(图1b)上显示一个无强化的鞍内囊肿，呈等信号区。Gd-DTPA矢状图(图1C)和冠状图(图1D)
Dear Editor, Rathke’s cleft cysts (RCCs) usually originate from the remnants of Rathke’s pouch arising from the primitive stomodeum. Based on the embryology of Rathke’s cleft, it is possible to explain the locations of RCCs, even the ones reported in very rare regions, such as entirely in the suprasellar region [4, 9], sphenoid sinus [6], and sphenoclivus [3]. On the other hand, the embryological theory cannot explain the origin of a RCC located in the anterior pituitary lobe. We herein report the first case of RCC located entirely in the anterior pituitary lobe, and hypothesize that the origin of this RCC might have been the migration of epithelial cells from Rathke’s cleft into the anterior wall of Rathke’s pouch due to the expression of leukemia inhibitory factor (LIF), which is one of the known endogenous factors.A 32-year-old female was referred to our department with a pituitary mass lesion detected by magnetic resonance (MR) imaging associated with headaches. A neurological examination on admission showed no abnormalities. Endocrinological examinations were within the normal ranges on admission. MR imaging demonstrated a nonenhanced intrasellar cyst appearing as an isointense region on T1-weighted (Fig. 1a) and T2-weighted images (Fig. 1b). Gadolinium-DTPA sagittal (Fig. 1c) and coronal (Fig. 1d)