Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation
Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation
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DOI：
10.1021/acs.orglett.0c02700
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发表时间：
2020-10-02
期刊：
影响因子：
5.2
通讯作者：
Dong, Kaiwu
中科院分区：
文献类型：
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作者：
Feng, Sitian;Tang, Yitian;Dong, Kaiwu
光学活性宝石二氟化有机分子的合成由于其独特的性质在制药和农化领域引起了人们极大的兴趣。本文以高收率（83-99%）制备了一系列富含对映体的α， α -二氟- β -芳基丁酸酯，具有中等至优异的对映选择性(
Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched alpha,alpha-difluoro-beta-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (