Expanded Distribution of Pain as a Sign of Central Sensitization in Individuals With Symptomatic Knee Osteoarthritis
Expanded Distribution of Pain as a Sign of Central Sensitization in Individuals With Symptomatic Knee Osteoarthritis
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DOI：
10.2522/ptj.20150492
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发表时间：
2016-08-01
期刊：
影响因子：
3.2
通讯作者：
Nijs, Jo
中科院分区：
文献类型：
--
作者：
Lluch Girbes, Enrique;Duenas, Lirios;Nijs, Jo
背景疼痛的分布扩大被认为是中枢致敏（CS）的标志。膝关节骨关节炎（OA）患者的症状记录与CS之间的关系尚未得到充分研究。本研究的目的是检查使用疼痛图评估的疼痛区域是否与膝关节OA患者的CS和临床症状相关。这是一项横断面研究。研究了53例计划接受初次全膝关节置换术的膝关节OA患者。所有参与者使用一种新型的数字设备完成疼痛绘图，完成自我管理问卷，并通过定量感觉测试进行评估。分别为女性和男性生成疼痛频率图。计算斯皮尔曼相关系数以揭示疼痛面积和定量感觉测试与临床疼痛之间可能的相关性。疼痛频率图显示疼痛区域扩大，尤其是女性。疼痛区域扩大与膝关节疼痛严重程度增加相关（r（s）= 0.325，P
Background. Expanded distribution of pain is considered a sign of central sensitization (CS). The relationship between recording of symptoms and CS in people with knee osteoarthritis (OA) has been poorly investigated.Objective. The aim of this study was to examine whether the area of pain assessed using pain drawings relates to CS and clinical symptoms in people with knee OA.Design. This was a cross-sectional study.Methods. Fifty-three people with knee OA scheduled to undergo primary total knee arthroplasty were studied. All participants completed pain drawings using a novel digital device, completed self-administration questionnaires, and were assessed by quantitative sensory testing. Pain frequency maps were generated separately for women and men. Spearman correlation coefficients were computed to reveal possible correlations between the area of pain and quantitative sensory testing and clinical symptoms.Results. Pain frequency maps revealed enlarged areas of pain, especially in women. Enlarged areas of pain were associated with higher knee pain severity (r(s) = .325, P