Sex Differences in the Sympathetic Neural Recruitment and Hemodynamic Response to Head-Up Tilt in Older Hypertensives
Sex Differences in the Sympathetic Neural Recruitment and Hemodynamic Response to Head-Up Tilt in Older Hypertensives
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DOI：
10.1161/hypertensionaha.119.14009
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发表时间：
2020-02-01
期刊：
影响因子：
8.3
通讯作者：
Fu, Qi
中科院分区：
文献类型：
--
作者：
Badrov, Mark B.;Okada, Yoshiyuki;Fu, Qi
这项研究检验了以下假设：与老年高血压男性相比，老年高血压女性在直立应激反应中表现出增强的升压反应和异常的交感神经放电模式。我们评估了老年高血压和血压正常男性和女性（每组 n=12）的血压、心率、心脏指数（乙炔再呼吸）、总外周阻力和肌肉交感神经活动（显微神经造影）在基线（仰卧；3 分钟）和分级抬头倾斜期间（30 度持续 5 分钟和 60 度持续 20 分钟）。使用基于小波的方法研究交感神经动作电位放电模式。在直立姿势下，与高血压男性和血压正常女性相比，高血压女性的收缩压和舒张压反应更大（P
This study tested the hypothesis that older hypertensive women display augmented pressor responses and aberrant sympathetic neural discharge patterning in response to orthostatic stress versus older hypertensive men. We evaluated, in older hypertensive and normotensive men and women (n=12 each group), blood pressure, heart rate, cardiac index (acetylene rebreathing), total peripheral resistance, and muscle sympathetic nerve activity (microneurography) at baseline (supine; 3 minutes) and during graded head-up tilt (30 degrees for 5 minutes and 60 degrees for 20 minutes). Sympathetic action potential discharge patterns were studied using wavelet-based methodology. In the upright posture, systolic and diastolic blood pressure responses were greater in hypertensive women versus hypertensive men and normotensive women (P