Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans.
Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans.
复制标题
人体口服10种非甾体镇痛药对血小板聚集的影响。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
I. Söderberg
中科院分区：
文献类型：
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作者：
S. Cronberg;E. Wallmark;I. Söderberg
研究了正常志愿者在摄入10种镇痛药物前和摄入后不同时间的富血小板血浆中的血小板聚集。使用的药物为阿司匹林、吡罗昔康、萘普生、吲哚美辛、双氯芬酸、布洛芬、二氟尼柳、扑热息痛和羟保泰松。用肾上腺素或ADP诱导血小板聚集，并评价第一和第二波聚集。结果发现，没有药物对第一波聚集产生任何影响。第二波聚集被阿司匹林所消除，并产生持续5- 8d的作用。吡罗昔康也能抑制第二波聚集，这种作用持续到第二天。在第2天，一半志愿者的尿钠正常化。吲哚美辛和双氯芬酸的抑制作用在第2天被纠正。伊立替尼和二氟尼柳产生了明确的但短期的效果。水杨酸的作用较弱。扑热息痛和羟保泰松不影响血小板聚集。
Platelet aggregation was investigated in platelet-rich plasma from normal volunteers before and at various times after intake of 10 analgesic drugs. The drugs used were aspirin, piroxicam, naproxen, indomethacin, diclofenac, ibuprofen, diflunisal, paracetamol and oxyphenbutazone. Aggregation of the platelets was induced by adrenaline or ADP and the first and second waves of aggregation were evaluated. It was found that no drug exerted any effect on the first wave of aggregation. The second wave of aggregation was abolished by aspirin that produced a long-lasting effect for 5-8 d. Piroxicam also abolished the second wave of aggregation and this effect persisted on the 2 following d. Naproxen was normalized in half of the volunteers on the 2nd d. The inhibition caused by indomethacin and diclofenac was corrected on the 2nd d. Ibuprofen and diflunisal produced a definite but short-term effect. The effect of salicylic acid was weak. Paracematol and oxyphenbutazone did not affect platelet aggregation.