Executive functioning in familial bipolar I disorder patients and their unaffected relatives.
Executive functioning in familial bipolar I disorder patients and their unaffected relatives.
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DOI：
10.1111/j.1399-5618.2011.00901.x
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发表时间：
2011-03
影响因子：
5.4
通讯作者：
K. Schulze;M. Walshe;D. Ståhl;M. Hall;E. Kravariti;R. Morris;N. Marshall;C. Mcdonald;R. Murray;E. Bramon
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文献类型：
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作者：
K. Schulze;M. Walshe;D. Ståhl;M. Hall;E. Kravariti;R. Morris;N. Marshall;C. Mcdonald;R. Murray;E. Bramon
目的比较有精神病症状史的家族性双相情感障碍(BP-I)患者与其一级亲属及正常对照的执行功能。方法对44例终生诊断为BP-I的家族性精神病患者、42例其未受影响的一级亲属和47例对照组进行执行功能三个领域的评估：反应抑制、工作记忆和认知定势转移。结果双相情感障碍患者及其正常亲属的反应抑制得分明显低于正常对照组。这两组人在工作记忆或认知定势转移方面没有区别。结论反应抑制障碍与精神病性双相情感障碍和该病的遗传易感性有关。我们的结果表明，执行功能这一特定领域的缺陷是精神病性双相情感障碍的一个有希望的候选内表型。
OBJECTIVE To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls. METHODS Three domains of executive function: response inhibition, working memory, and cognitive set shifting were assessed in 44 familial patients with a lifetime diagnosis of BP-I who had experienced psychotic symptoms, 42 of their unaffected first-degree relatives, and 47 controls. RESULTS Bipolar disorder patients and their unaffected relatives had significantly worse scores for response inhibition compared to healthy controls. The groups did not differ in working memory or cognitive set shifting. CONCLUSIONS Impairments in response inhibition are associated with both psychotic bipolar disorder and genetic liability for this illness. Our results indicate that deficits in this specific domain of executive functioning are a promising candidate endophenotype for psychotic bipolar disorder.