Functionalized hydrogels in ophthalmic applications: Ocular inflammation, corneal injuries, vitreous substitutes and intravitreal injection
Functionalized hydrogels in ophthalmic applications: Ocular inflammation, corneal injuries, vitreous substitutes and intravitreal injection
复制标题
功能化水凝胶在眼科应用：眼部炎症、角膜损伤、玻璃体替代物和玻璃体内注射
DOI：
10.1016/j.matdes.2022.111277
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发表时间：
2022-10-27
影响因子：
8.4
通讯作者：
Li, Zuhao
中科院分区：
文献类型：
--
作者：
Gong, Qiaoyun;Zhao, Yue;Li, Zuhao
随着眼部炎症、角膜损伤、白内障、青光眼、视网膜变性等眼部疾病的流行，人们开发了不同的临床治疗策略，但在实际应用中仍存在许多不可避免的缺陷。功能化水凝胶具有良好的生物相容性、接近生理的细胞外基质环境、可注射性、可剪裁的结构、固有的柔韧性、动态可调的机械性能、特别有吸引力的自粘附性、令人羡慕的细胞递送和持续药物释放能力等优点，已成为眼科应用中极具吸引力的材料和革命性策略。本文综述了近年来用于眼科疾病治疗的功能化水凝胶的研究进展。本文还系统地介绍了其在眼科应用方面的最新研究进展，包括治疗浅表炎症的局部给药、角膜损伤的敷料、青光眼视神经病变的注射给药系统、玻璃体切除术后的玻璃体替代物、眼内疾病的玻璃体内给药等。阐述了工程水凝胶在眼科疾病治疗中面临的科学挑战和尚未开发的潜力，以展示其未来的前景。本文旨在提供比较的视角和多方面的见解，以激发对水凝胶的更深入的研究，并为其在眼科的各种应用提供指导。(c)2022年，任作家。由爱思唯尔有限公司出版。这是一篇在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
With the prevalence of eye diseases, such as inflamed eyes, corneal injury, cataract, glaucoma, and retinal degenerative diseases, different clinical strategies have been developed, however, they still suffer from many inevitable drawbacks in practical applications. Functionalized hydrogels have emerged as attrac-tive materials and revolutionary strategies for ophthalmic applications owing to their favorable proper-ties, such as excellent biocompatibility, near-physiological extracellular matrix environment, injectability, tailorable structure, inherent flexibility, dynamically adjustable mechanical properties, par-ticularly attractive self-adhesion, enviable cell delivery, and sustained drug release capabilities. In this review, various functionalized hydrogels for different ophthalmic diseases have been comprehensively summarized. The review also systematically introduces the advanced research progress in ophthalmic applications, including topical administration for superficial inflamed eyes, dressings for corneal injuries, injectable drug delivery system for glaucomatous optic neuropathy, vitreous substitutes after vitrectomy, intravitreal administration for intraocular diseases, and etc. Finally, the scientific challenges and untapped potential are expounded to demonstrate the future prospects of engineered hydrogels for the treatment of ocular diseases. The review aims to provide comparative perspectives and multifaceted insights to inspire more in-depth research on hydrogels and provide guidance for their varied applica-tions in ophthalmology.(c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).