The Relationship of Blood Product Ratio to Mortality: Survival Benefit or Survival Bias?
The Relationship of Blood Product Ratio to Mortality: Survival Benefit or Survival Bias?
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DOI：
10.1097/ta.0b013e318196c3ac
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发表时间：
2009-02-01
影响因子：
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通讯作者：
Kerby, Jeffrey D.
中科院分区：
文献类型：
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作者：
Snyder, Christopher W.;Weinberg, Jordan A.;Kerby, Jeffrey D.
背景：最近的研究表明，使用较高的新鲜冰冻血浆(FFP)与红细胞(PRBC)累积比率具有明显的生存优势。目前尚不清楚时间因素和生存偏见如何影响这些结果。本研究的目的是评估大量输血创伤患者血液产品比率与死亡率之间的时间关系。方法：选择2005-2007年间需要大量输血(入院后24小时内输注10单位PRBC)的患者(n=134)。接受高剂量(1：2)和低剂量(>；1：2)治疗的患者的住院死亡率进行了比较。
Background: Recent studies show an apparent survival advantage associated with the administration of higher cumulative ratios of fresh frozen plasma (FFP) to packed red blood cells (PRBC). It remains unclear how temporal factors and survival bias may influence these results. The objective of this study was to evaluate the temporal relationship between blood product ratios and mortality in massively transfused trauma patients.Methods: Patients requiring massive transfusion (>10 units of PRBC within 24 hours of admission) between 2005 and 2007 were identified (n = 134). In-hospital mortality was compared between patients receiving high (>1:2) versus low (