A Prospective, Randomized, Double-Blinded Trial Comparing Acetaminophen, Ibuprofen and Oxycodone for Pain Management After Hand Surgery
A Prospective, Randomized, Double-Blinded Trial Comparing Acetaminophen, Ibuprofen and Oxycodone for Pain Management After Hand Surgery
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DOI：
10.3928/01477447-20190221-02
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发表时间：
2019-03-01
期刊：
影响因子：
1.1
通讯作者：
Matzon, Jonas L.
中科院分区：
文献类型：
--
作者：
Ilyas, Asif M.;Miller, Andrew J.;Matzon, Jonas L.
本研究的目的是评估3种常用的口服镇痛药——羟考酮（OXY）、布洛芬（IBU）和对乙酰氨基酚（ACE）——在腕管释放（CTR）和手指释放（TFR）手术后的疼痛管理。结果测量是疼痛评分、胶囊消费模式和满意度。腕管或扳机指患者指征原发性单侧手术后接受10粒OXY （5mg）、IBU （600mg）或ACE （500mg）胶囊。药物以随机方式分配，药物和患者均对所选镇痛药不知情。术后，患者使用0 - 10级视觉模拟量表记录每天的疼痛程度，每天服用的胶囊数量，以及所经历的任何不良反应。188例完成研究的患者中，药物分布为62例OXY， 64例IBU， 62例ACE。手术分布为TFR 76例，内窥镜CTR 61例，开放式CTR 51例。总体而言，OXY、IBIJ和ACE术后0 - 5天的平均总胶囊消耗量分别为3.2、4.0和3.1 （P < 0.05）。OXY组、IBU组和ACE组的平均每日最差疼痛评分分别为2.9、2.5和2.5
The goal of this was to evaluate 3 common oral analgesics-oxycodone (OXY), ibuprofen (IBU), and acetaminophen (ACE)-for pain management following carpal tunnel release (CTR) and tigger finger release (TFR) surgery. Outcome measures were pain scores, capsule consumption patterns, and satisfaction.Carpal tunnel or trigger finger patients indicated to undergo primary, unilateral received 10 capsules of either OXY (5 mg), IBU (600 mg), or ACE (500 mg) postoperatively. Medications were distributed in a randomized fashion, with both surge(ins arid patient; blinded to the selected analgesic. Postoperatively, patients recorded pain level each day using a 0 to 10 visual analog scale, the number of capsules taken each day, and any adverse effects experienced. Medication distribution among the 188 patients completing the study was 62 OXY, 64 IBU, and 62 ACE. Surgical distribution was 76 TFR, 61 endoscopic CTR, and 51 open CTR. Overall, the mean total number of capsules consumed from postoperative days 0 through 5 for OXY, IBIJ, and ACE was 3.2, 4.0, and 3.1, respectively (P>.05). Mean worst daily pain score for the OXY, IBU , and ACE groups was 2.9, 2.5, and 2.5, respectively (P