PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
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DOI：
10.1097/qad.0b013e3282eee548
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发表时间：
2007-10-01
期刊：
影响因子：
3.8
通讯作者：
Appay, Victor
中科院分区：
文献类型：
--
作者：
Sauce, Delphine;Almeida, Jorge R.;Appay, Victor
目标和设计：最近报道HIV特异性CD 8 T细胞上的PD-1表达反映了功能衰竭，导致HIV-1复制失控。评估T细胞上的PD-1表达可能与T细胞免疫学和疫苗监测高度相关。然而，这需要我们进一步深入了解PD-1在人类CD 8 T细胞上表达的意义。方法：我们对来自健康或HIV感染供体的各种CD 8 T细胞亚群上的PD-1表达模式进行了详细的分析。一方面，它与T细胞分化有关：PD-1在早期/中期分化的亚群中上调，包括HIV和EB病毒特异性CD 8 T细胞群，但在分化的晚期阶段下调。另一方面，它与T细胞活化有关：在PD-1阳性细胞上，PD-1过表达沿着活化标志物如CD 38或HLA-DR的上调。结论：CD 8 T细胞上的PD-1表达，包括HIV特异性T细胞，可能与其分化阶段和活化状态有关。在评估PD-1在T细胞上的表达时，考虑这些发现很重要。(C)2007年利平科特威廉姆斯&威尔金斯。
Objective and design: PD-1 expression on HIV-specific CD8 T cells was recently reported to reflect functional exhaustion, resulting in uncontrolled HIV-1 replication. Assessing PD-1 expression on T cells may be highly relevant in T-cell immunology and vaccine monitoring. However, this requires us to gain further insights into the significance of PD-1 expression on CD8 T cells in humans.Methods: We performed a detailed analysis of PD-1 expression pattern on various CD8 T cell subsets from healthy or HIV infected donors.Results: PD-1 expression has two facets in vivo. On the one hand, it is linked to T-cell differentiation: PD-1 is up-regulated on early/intermediate differentiated subsets, which include HIV and Epstein-Barr virus-specific CD8 T-cell populations, but is down-regulated during late stages of differentiation. On the other hand, it is linked to T-cell activation: on PD-1 positive cells, PD-1 over-expression occurs along with the up-regulation of activation markers such as CD38 or HLA-DR.Conclusions: PD-1 expression on CD8 T cells, including those specific for HIV, can be related both to their differentiation stage and their activation status. It is important to consider these findings when assessing the expression of PD-1 on T cells. (C) 2007 Lippincott Williams & Wilkins.