VASODILATION OF RAT RETINAL MICROVESSELS INDUCED BY MONOBUTYRIN - DYSREGULATION IN DIABETES
VASODILATION OF RAT RETINAL MICROVESSELS INDUCED BY MONOBUTYRIN - DYSREGULATION IN DIABETES
复制标题
DOI：
10.1172/jci116908
复制
发表时间：
1993-12-01
影响因子：
15.9
通讯作者：
SPIEGELMAN, BM
中科院分区：
文献类型：
--
作者：
HALVORSEN, YDC;BURSELL, SE;SPIEGELMAN, BM
1-丁酰甘油（单丁酸甘油酯）是脂肪细胞的简单脂质产物，具有血管生成活性。最近的研究表明，这种化合物的生物合成与脂解密切相关，脂解是一种与血流变化相关的过程。我们现在提出的数据表明，monobutyrin是一种有效的啮齿动物血管扩张剂，使用荧光视网膜血管造影分析。monobutyrin的血管舒张活性是有效的（ED 50 = 3.3 × 10（-7）M），剂量依赖性和立体特异性。由于糖尿病是一种分解代谢、脂肪分解的状态，伴有许多血管并发症，我们研究了单丁酸甘油酯在胰岛素缺乏型糖尿病大鼠中的作用和调节。链脲佐菌素诱导的糖尿病大鼠血清中的单丁酸甘油酯水平大大高于正常动物。同时，糖尿病动物的视网膜血管对单丁酸甘油酯的血管舒张活性产生抗性。这些结果证明了单丁酸甘油酯在控制血管张力中的作用，并表明可能参与糖尿病的病理学。
1-Butyryl-glycerol (monobutyrin) is a simple lipid product of adipocytes with angiogenic activity. Recent studies have shown that the biosynthesis of this compound is tightly linked to lipolysis, a process associated with changes in blood flow. We now present data indicating that monobutyrin is an effective vasodilator of rodent blood vessels using a fluorescent retinal angiogram assay. The vasodilatory activity of monobutyrin is potent (ED50 = 3.3 x 10(-7) M), dose dependent, and stereospecific. Because diabetes represents a catabolic, lipolytic state with numerous vascular complications, we examined the action and regulation of monobutyrin in insulin-deficient diabetic rats. Serum levels of monobutyrin in streptozotocin-induced diabetic rats were greatly elevated compared to normal animals. At the same time, the retinal vessels of the diabetic animals develop a resistance to the vasodilatory activity of monobutyrin. These results demonstrate a role for monobutyrin in the control of vascular tone and suggest a possible involvement in the pathology of diabetes.