Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat
Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat
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DOI：
10.1016/s0892-0362(96)00216-4
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发表时间：
1997-03-01
影响因子：
2.9
通讯作者：
RodriguezFarre, E
中科院分区：
文献类型：
--
作者：
Llorens, J;RodriguezFarre, E
亚慢性 3,3'-亚氨基二丙腈 (IDPN) 的作用在成年 Long-Evans 雄性大鼠中进行了表征。在一项预备实验中，急性 IDPN（890 mg/kg，IF）和鼓室内阿散酸引起了类似的运动活动、站立和前庭损伤评分的改变。在第二个预备实验中，饮用水中的 IDPN（0%、0.025%、0.05%、0.1%、0.2% 或 0.4%）导致水摄入量呈浓度依赖性减少，但 IDPN 摄入量有效增加。亚慢性实验中，大鼠均暴露于上述浓度的IDPN 15周，但0.4%组仅暴露7周。观察 0.2% 和 0.4% IDPN 后对体重、运动活动、前庭评分、前庭形态和轴突直径的影响。 0.05% 和 0.1% IDPN 出现近端轴突病变，但很少或没有临床症状或前庭毒性。我们得出的结论是，亚慢性 IDPN 在剂量大于轴突病变剂量时可诱导前庭毛细胞损失，并且前庭毒性（而不是轴突病变）是造成 IDPN 暴露特征的行为总体变化的原因。 (C) 1997 爱思唯尔科学公司。
The effects of subchronic 3,3'-iminodipropionitrile (IDPN) were characterized in the adult Long-Evans male rat. In a preparatory experiment, acute IDPN (890 mg/kg, IF) and intratympanic arsanilic acid caused similar alterations in locomotor activity, rearings, and scores for vestibular impairment. In a second preparatory experiment, IDPN in the drinking water (0%, 0.025%, 0.05%, 0.1%, 0.2%, or 0.4%) caused a concentration-dependent decrease in water intake, but a effective increase in IDPN intake. In the subchronic experiment, rats were exposed to the above concentrations of IDPN for 15 weeks, except the 0.4% group, exposed for only 7 weeks. Effects on body weight, motor activity, vestibular scores, vestibular morphology, and axonal diameter were observed after 0.2% and 0.4% IDPN. Proximal axonopathies but little or no clinical signs or vestibular toxicity followed 0.05% and 0.1% IDPN. We concluded that vestibular hair cell loss can be induced by subchronic IDPN at doses larger than the axonopathic doses, and that the vestibular toxicity, not the axonopathy, is responsible for the gross changes in behavior characterizing IDPN exposure. (C) 1997 Elsevier Science Inc.