Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China
Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China
复制标题
中国中部和东部地区 414,540 名女性 hrHPV 感染流行情况及特征：一项多中心研究
DOI：
10.7150/jca.30157
复制
发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Wu, Peng
中科院分区：
文献类型：
--
作者：
Wang, Yi;Meng, Yifan;Wu, Peng
目的：利用基于美国fda批准的检测方法的大规模多中心数据了解高危人乳头瘤病毒（hrHPV）的流行和特征，对指导中国正在进行的疫苗接种计划具有重要意义。方法：基于中国中东部地区11家大型医院的资料进行回顾性观察研究。2012年10月1日至2016年12月31日，共收集480,034份宫颈标本，纳入414,540名符合条件的参与者（14-80岁，平均年龄39.9岁），并使用Cervista高危HPV检测（Hologic Inc., Bedford, Mass， USA）进行检测。结果：武汉市hrHPV总患病率为17.8%(73713 / 414540)，略高于浙江省（18.6% vs. 17.6%, P < 0.001）。2012 - 2016年患病率呈下降趋势。最常见的hrHPV组是A9(61.7%)，其次是A5/A6（29.4%）和A7（25.6%）。年龄特异性hrHPV患病率呈u型曲线：≤19岁和≥50岁高于其他年龄组。结论：在疫苗接种前，A9是最占优势的hrHPV组，感染最容易发生在年轻人和老年人。hrHPV的流行率因城市和年龄组而异，这表明疫苗接种计划应以特定人群的方式进行宣传。
Objectives: Understanding the prevalence and characteristics of high-risk human papillomavirus (hrHPV) with the large-scale multicenter data based on a US FDA-approved testing method is important to guide ongoing vaccination programs in China. Methods: We conducted a retrospective observational study based on data from 11 large hospitals in central and eastern China. From October 1st, 2012 to December 31st, 2016, a total of 480,034 cervical specimens were collected, and 414,540 eligible participants (14-80 years, mean age 39.9 years) were included and tested using Cervista High-Risk HPV Assay (Hologic Inc., Bedford, Mass, USA). Results: The overall hrHPV prevalence in this study was 17.8% (73,713/414,540), with Wuhan slightly higher than Zhejiang (18.6% vs. 17.6%, P < 0.001). The prevalence showed a declining trend from 2012 to 2016. The most common hrHPV group was A9 (61.7%), followed by A5/A6 (29.4%) and A7 (25.6%). A U-shaped curve was observed for age-specific hrHPV prevalence: ≤19 years and ≥50 years were higher than other age groups. Conclusion: In pre-vaccination period, A9 was the most dominant hrHPV group, and infections were most likely to occur at younger and older ages. The prevalence of hrHPV varied by cities and age groups, suggesting vaccination programs should be propagated in a population-specific approach.