Role of growth factors and endothelial cells in therapeutic angiogenesis and tissue engineering.
Role of growth factors and endothelial cells in therapeutic angiogenesis and tissue engineering.
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DOI：
10.2174/157488806778226777
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发表时间：
2006-08
影响因子：
2.7
通讯作者：
M. Nomi;H. Miyake;Y. Sugita;M. Fujisawa;S. Soker
中科院分区：
文献类型：
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作者：
M. Nomi;H. Miyake;Y. Sugita;M. Fujisawa;S. Soker
为了实现大型复杂组织和可能的内部器官的工程目标，再生组织的血管化是必不可少的。为了维持再生组织植入后的初始体积，改善血管化被认为是重要的。血管生长过程的最新进展为生物工程组织的新生血管和治疗性血管生成提供了重要的工具。几种血管生成生长因子包括血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）和肝细胞生长因子（HGF）用于缺血组织的血管化。其他方法，如支架预血管化，在细胞播种之前，以及将内皮细胞掺入生物工程组织中显示出令人鼓舞的结果。本文将综述近年来血管生成生长因子的研究进展，并讨论这些生长因子和内皮细胞在治疗性血管生成和组织工程中的作用。
To achieve the goals of engineering large complex tissues, and possibly internal organs, vascularization of the regenerating tissue is essential. To maintain the initial volume after implantation of regenerated tissue, improved vascularization is considered to be important. Recent advances in understanding the process of blood vessel growth has offered significant tools for the neovascularization of bioengineered tissues and therapeutic angiogenesis. Several angiogenic growth factors including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF) were used for vascularization of ischemic tissues. Other approaches such as prevascularization of the scaffold, prior to cell seeding, and incorporation of endothelial cells in the bioengineered tissue showed encouraging results. In this article, we will review recent advances in angiogenic growth factors, and discuss the role of these growth factors and endothelial cells in therapeutic angiogenesis and tissue engineering.