DETERMINANTS OF VARIATIONS IN BREAST-MILK PROTECTIVE FACTOR CONCENTRATIONS OF RURAL GAMBIAN MOTHERS
DETERMINANTS OF VARIATIONS IN BREAST-MILK PROTECTIVE FACTOR CONCENTRATIONS OF RURAL GAMBIAN MOTHERS
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DOI：
10.1136/adc.58.7.518
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发表时间：
1983-01-01
影响因子：
5.2
通讯作者：
WHITEHEAD, RG
中科院分区：
文献类型：
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作者：
PRENTICE, A;PRENTICE, AM;WHITEHEAD, RG
作为半长期研究的一部分，测量了152名西非农村妇女母乳中7种免疫蛋白（伊加、IgG、IgM、补体成分C3和C4、乳铁蛋白和溶菌酶）的浓度，以评估其对婴儿健康[特别是传染病]的重要性。每个母亲都保持着相对于其他母亲的免疫蛋白质生产的特征水平，并且每个妇女体内的每种免疫蛋白质的浓度与其他人呈正相关。产次是排名的主要决定因素，产次1和2的母亲产生的免疫蛋白浓度最高。除溶菌酶外，婴儿对这些保护因子的摄入量在哺乳早期有所下降，但1-2岁的婴儿仍能获得大量的保护因子。冈比亚婴儿的每日摄入量与英国剑桥的婴儿相似或更高。婴儿发病率的明显季节性增加并不伴随着母乳中保护因子浓度的增加。
The concentrations of 7 immunoproteins (IgA, IgG, IgM, the complement components C3 and C4, lactoferrin, and lysozyme) in the breast milk of 152 rural west African women were measured as part of a semilongitudinal study to assess their importance in infant health [especially infectious disease]. Each mother maintained a characteristic level of production of immunoproteins relative to other mothers, and the concentration of each immunoprotein within each woman was correlated positively with the others. Parity was the major determinant of ranking and mothers of parity 1 and 2 produced the highest concentrations of immunoproteins. Except for lysozyme, infants'' intake of these protective factors decreased in early lactation, but infants aged 1-2 yr still received substantial amounts. The daily intakes by Gambian infants were similar to or higher than those of infants in Cambridge, UK. A marked seasonal increase in infant morbidity was not accompanied by an increase in the concentrations of protective factors in mothers'' milk.