ADHD symptoms are associated with the modular structure of intrinsic brain networks in a representative sample of healthy adults
ADHD symptoms are associated with the modular structure of intrinsic brain networks in a representative sample of healthy adults
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DOI：
10.1162/netn_a_00083
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发表时间：
2019-01-01
影响因子：
4.7
通讯作者：
Fiebach, Christian J.
中科院分区：
文献类型：
--
作者：
Hilger, Kirsten;Fiebach, Christian J.
注意力缺陷/多动障碍 (ADHD) 是最常见的神经发育障碍之一，对社交、情感和认知功能具有显着且往往是终生的影响。 ADHD 有影响力的神经认知模型将行为症状与功能性大脑网络之间和内部的连接改变联系起来。在这里，我们研究基于网络的 ADHD 理论是否可以推广到理解正常（即临床上未受影响的）成年人群中 ADHD 相关行为的变化。在一个大的、有代表性的样本中，自评的多动症症状存在很大差异； 291 名参与者中只有 8 名得分处于临床范围内。受试者特定的大脑网络图是根据功能性 MRI 静息态数据建模的，并揭示了（非临床）ADHD 症状与模块间和模块内连接的区域特定特征之间的显着关联。效应位于与多个神经元系统相关的大脑区域，包括默认模式网络、显着网络和中央执行系统。我们的结果与 ADHD 的网络观点一致，并为任务消极（默认模式）和任务积极大脑区域之间适当的信息传递的相关性提供了进一步的证据。更一般地说，我们的研究结果支持 ADHD 的维度概念化，并有助于加深对认知作为功能性大脑网络的新兴属性的理解。作者摘要 ADHD 的神经认知模型将行为症状与功能性大脑网络之间和内部的连接改变联系起来。我们研究这些基于网络的 ADHD 理论是否可以推广到正常成年人群中与 ADHD 相关的行为。受试者特定脑图是根据大型代表性样本 (N = 291) 的功能性 MRI 静息态数据建模的。在与多个功能系统（包括默认模式网络、显着网络和中央执行系统）相关的大脑区域中观察到 ADHD 相关行为与模块间和模块内连接的区域特异性概况之间存在显着关联。我们的结果支持 ADHD 的维度概念化，并通过为任务消极（默认模式）和任务积极大脑区域之间适当的信息传递的相关性提供进一步的证据来强化基于网络的 ADHD 模型。
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders with significant and often lifelong effects on social, emotional, and cognitive functioning. Influential neurocognitive models of ADHD link behavioral symptoms to altered connections between and within functional brain networks. Here, we investigate whether network-based theories of ADHD can be generalized to understanding variations in ADHD-related behaviors within the normal (i.e., clinically unaffected) adult population. In a large and representative sample, self-rated presence of ADHD symptoms varied widely; only 8 out of 291 participants scored in the clinical range. Subject-specific brain network graphs were modeled from functional MRI resting-state data and revealed significant associations between (nonclinical) ADHD symptoms and region-specific profiles of between-module and within-module connectivity. Effects were located in brain regions associated with multiple neuronal systems including the default-mode network, the salience network, and the central executive system. Our results are consistent with network perspectives of ADHD and provide further evidence for the relevance of an appropriate information transfer between task-negative (default-mode) and task-positive brain regions. More generally, our findings support a dimensional conceptualization of ADHD and contribute to a growing understanding of cognition as an emerging property of functional brain networks.Author Summary Neurocognitive models of ADHD link behavioral symptoms to altered connections between and within functional brain networks. We investigate whether these network-based theories of ADHD can be generalized to ADHD-related behaviors within the normal adult population. Subject-specific brain graphs were modeled from functional MRI resting-state data of a large and representative sample (N = 291). Significant associations between ADHD-related behaviors and region-specific profiles of between-module and within-module connectivity were observed in brain regions associated with multiple functional systems including the default-mode network, the salience network, and the central executive system. Our results support a dimensional conceptualization of ADHD and enforce network-based models of ADHD by providing further evidence for the relevance of an appropriate information transfer between task-negative (default-mode) and task-positive brain regions.