Isolation of a Se-nitrososelenol:: A new class of reactive nitrogen species relevant to protein Se-nitrosation
Isolation of a Se-nitrososelenol:: A new class of reactive nitrogen species relevant to protein Se-nitrosation
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DOI：
10.1021/ja0457009
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发表时间：
2004-10-20
影响因子：
15
通讯作者：
Nagase, S
中科院分区：
文献类型：
--
作者：
Shimada, K;Goto, K;Nagase, S
一氧化氮（NO）是参与许多生理过程的信使分子。硒蛋白的亚硝化作用被认为在no介导的细胞功能中起重要作用，如谷胱甘肽过氧化物酶（GPx）的失活，但迄今为止还没有关于硒亚硝化种类的化学信息。本文合成了一类新的NO衍生物——稳定的RSeNO -亚硝基硒醇（RSeNO），并用x射线晶体学和光谱方法对其进行了表征。这种se -亚硝基硒醇可以通过ans -亚硝基硫醇直接转亚硝化成硒醇而形成，正如所提出的no介导GPx失活的机制一样。
Nitric oxide (NO) is a messenger molecule implicated in a number of physiological processes. Nitrosation of selenoproteins has been suggested as playing an important role in NO-mediated cellular functions such as the inactivation of glutathione peroxidase (GPx), but no chemical information aboutSe-nitrosated species has been available to date. Here a stableSe-nitrososelenol (RSeNO), a new class of NO derivative, was synthesized and fully characterized by X-ray crystallography and spectroscopic methods. ThisSe-nitrososelenol can be formed by direct transnitrosation from anS-nitrosothiol to a selenol, as is the case in the proposed mechanism for the NO-mediated inactivation of GPx.