A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients
A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients
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DOI：
10.4103/0970-0358.59276
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发表时间：
2009-07-01
影响因子：
0.8
通讯作者：
Randa, R.
中科院分区：
文献类型：
--
作者：
Baghel, P. S.;Shukla, S.;Randa, R.
比较蜂蜜敷料和磺胺嘧啶银（SSD）敷料对烧伤患者伤口愈合的影响。该研究纳入了为期 2 年（2006 年 8 月）的男女患者（n = 78），年龄在 10 至 50 岁之间，一级和二级烧伤低于 TBSA（体表面积）的 50%。病情稳定后，患者被随机分为两组：“蜂蜜组”和“SSD 组”。记录烧伤后经过的时间。每天用生理盐水冲洗后，将未稀释的纯蜂蜜涂抹在蜂蜜组患者（n=37）的伤口上，将SSD霜涂抹在SSD组患者（n=41）的伤口上。伤口用无菌纱布、棉垫包扎并包扎。每第三天和第七天以及研究完成当天评估伤口状况。每两周对患者进行一次随访直至上皮化。每第七天对伤口进行一次细菌学检查。病例（蜂蜜组）和对照组（SSD 组）的平均年龄分别为 34.5 岁和 28.5 岁。烧伤后 8 小时内就诊的 36 名患者以及 24 小时后就诊的所有患者中，有 29 名患者的伤口拭子培养结果呈阳性。在入院任何时间接受蜂蜜和 SSD 敷料治疗的患者的平均愈合时间分别为 18.16 和 32.68 天。所有报告在 1 小时内报告的患者（100%）的伤口在使用蜂蜜敷料后不到 7 天就变得无菌，而没有使用 SSD。所有伤口在使用蜂蜜后不到 21 天就变得无菌，而 SSD 治疗伤口中只有 36.5% 的伤口达到了无菌状态。蜂蜜组有 33 名在受伤 24 小时内报告的患者，其中 26 名患者在 2 个月的随访中获得了完整的结果，而 SSD 组的人数分别为 32 名和 12 名。在 2 个月后的任何入院时间点，蜂蜜组和 SSD 组中分别有 81% 和 37% 的患者注意到完整的结果。与 SSD 敷料相比，蜂蜜敷料可以改善伤口愈合，在更短的时间内使伤口无菌，在预防肥厚性疤痕和烧伤后挛缩方面具有更好的效果，并且无论入院时间如何，都可以减少清创的需要。
To compare the effect of honey dressing and silver- sulfadiazene (SSD) dressing on wound healing in burn patients. Patients (n=78) of both sexes, with age group between 10 and 50 years and with first and second degree of burn of less than 50% of TBSA (Total body surface area) were included in the study, over a period of 2 years (2006- 08). After stabilization, patients were randomly attributed into two groups: 'honey group' and 'SSD group'. Time elapsed since burn was recorded. After washing with normal saline, undiluted pure honey was applied over the wounds of patients in the honey group (n=37) and SSD cream over the wounds of patients in SSD group (n=41), everyday. Wound was dressed with sterile gauze, cotton pads and bandaged. Status of the wound was assessed every third and seventh day and on the day of completion of study. Patients were followed up every fortnight till epithelialization. The bacteriological examination of the wound was done every seventh day. The mean age for case (honey group) and control (SSD group) was 34.5 years and 28.5 years, respectively. Wound swab culture was positive in 29 out of 36 patients who came within 8 hours of burn and in all patients who came after 24 hours. The average duration of healing in patients treated with honey and SSD dressing at any time of admission was 18.16 and 32.68 days, respectively. Wound of all those patients (100%) who reported within 1 hour became sterile with honey dressing in less than 7 days while none with SSD. All of the wounds became sterile in less than 21 days with honey, while tthis was so in only 36.5% with SSD treated wounds. The honey group included 33 patients reported within 24 hour of injury, and 26 out of them had complete outcome at 2 months of follow- up, while numbers for the SSD group were 32 and 12. Complete outcome for any admission point of time after 2 months was noted in 81% and 37% of patients in the honey group and the SSD group. Honey dressing improves wound healing, makes the wound sterile in lesser time, has a better outcome in terms of prevention of hypertrophic scarring and postburn contractures, and decreases the need of debridement irrespective of time of admission, when compared to SSD dressing.