Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma.
Gastrointestinal intraluminal pH in normal subjects and those with colorectal adenoma or carcinoma.
复制标题
正常受试者和结直肠腺瘤或癌患者的胃肠腔内 pH 值。
作者：
G. Pye;D. Evans;S. Ledingham;J. Hardcastle
最近的证据表明，当结肠内容物的pH值为碱性时，促进结直肠致癌物的产生。因此，结肠直肠肿瘤患者的结肠腔内pH值应高于正常受试者。在30例结直肠癌患者和37例良性结直肠腺瘤患者中测量了胃肠道pH值（使用pH敏感的无线电遥测胶囊）。这些值已与66例正常人的记录进行了比较。没有发现胃肠道pH值的差异，结果不支持结肠pH值在结直肠肿瘤病因学中起作用的假设。
Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with colorectal cancer and 37 patients with benign colorectal adenomas (using a pH sensitive radiotelemetry capsule). These values have been compared with those recorded in 66 normal subjects. No differences in gastrointestinal pH were found and the results did not support the hypothesis that colonic pH plays a role in the aetiology of colorectal neoplasia.