Extrathoracic and intrathoracic removal of O3 in tidal-breathing humans.
Extrathoracic and intrathoracic removal of O3 in tidal-breathing humans.
复制标题
潮汐呼吸人类的胸外和胸内 O3 去除。
DOI：
10.1152/jappl.1988.65.1.393
复制
发表时间：
1988
影响因子：
3.3
通讯作者：
J. O'neil
中科院分区：
文献类型：
--
作者：
T. Gerrity;R. A. Weaver;J. Berntsen;D. House;J. O'neil
我们测量了18名健康、不吸烟的年轻男性志愿者通过胸外和胸内气道从吸入空气中清除O3的效率。去除效率作为O3浓度（0.1，0.2和0.4 ppm），呼吸模式（鼻子，嘴，口鼻）和呼吸频率（12和24呼吸/分钟）的函数进行测量。受试者被放置在一个受控的环境室，其中O3被引入。然后将一根小聚乙烯管插入每名受试者的鼻子中，尖端位于咽后部。通过管子从后咽收集空气样本，并进入快速响应的O3分析仪，得到后咽中吸气和呼气的O3浓度。使用吸气浓度和腔室浓度计算胸外气道的O3去除效率，使用吸气浓度和呼气浓度计算胸内去除效率。所有测量的平均胸外切除效率为39.6 +/- 0.7%（SE），平均胸内切除效率为91.0 +/-0.5%。当受试者以24次呼吸/min呼吸时，与12次呼吸/min相比，胸外和胸内清除的O3显著较少（P <0.001）。O3浓度对胸外清除效率没有影响，但0.4ppm时的胸内清除效率显著高于0.1ppm（P <0.05）。呼吸方式显著影响胸外清除效率，鼻呼吸清除的O3少于口呼吸或口鼻呼吸（P <0.01）。（250字处删节）
We measured the efficiency of O3 removal from inspired air by the extrathoracic and intrathoracic airways in 18 healthy, nonsmoking, young male volunteers. Removal efficiencies were measured as a function of O3 concentration (0.1, 0.2, and 0.4 ppm), mode of breathing (nose only, mouth only, and oronasal), and respiration frequency (12 and 24 breaths/min). Subjects were placed in a controlled environmental chamber into which O3 was introduced. A small polyethylene tube was then inserted into the nose of each subject, with the tip positioned in the posterior pharynx. Samples of air were collected from the posterior pharynx through the tube and into a rapidly responding O3 analyzer yielding inspiratory and expiratory O3 concentrations in the posterior pharynx. The O3 removal efficiency of the extrathoracic airways was computed with the use of the inspiratory concentration and the chamber concentration, and intrathoracic removal efficiency was computed with the use of the inspiratory and expiratory concentrations. The mean extrathoracic removal efficiency for all measurements was 39.6 +/- 0.7% (SE), and the mean intrathoracic removal efficiency was 91.0 +/- 0.5%. Significantly less O3 was removed both extrathoracically and intrathoracically when subjects breathed at 24 breaths/min compared with 12 breaths/min (P less than 0.001). O3 concentration had no effect on extrathoracic removal efficiency, but there was a significantly greater intrathoracic removal efficiency at 0.4 ppm than at 0.1 ppm (P less than 0.05). Mode of breathing significantly affected extrathoracic removal efficiency, with less O3 removed during nasal breathing than during either mouth breathing or oronasal breathing (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)