Transcriptional control of Hox genes in the vertebrate nervous system
Transcriptional control of Hox genes in the vertebrate nervous system
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DOI：
10.1016/s0959-437x(96)80086-4
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发表时间：
1996-10-01
影响因子：
4
通讯作者：
Lufkin, T
中科院分区：
文献类型：
--
作者：
Lufkin, T
在转基因小鼠中，可以概括内源性基因表达模式某些方面的Hox基因DNA调控元件的鉴定取得了巨大的成功。然而，即使分析了跨越邻近基因的大基因组片段，完美复制正确的表达模式也是罕见的，这表明重要的调节区可能位于离它们控制的基因很远的地方，或者它们的特定背景可能很重要。最近发现了四种转录调控因子：视黄酸受体、Krox20、PBX/EXD家族和HOX基因本身，它们被证明可以直接调节小鼠神经系统中HOX基因的表达。
The identification, in transgenic mice, of Hox gene DNA regulatory elements that can recapitulate certain aspects of the endogenous gene expression pattern has proceeded with great success. Perfect reproduction of the correct expression pattern, however, is uncommon, even when large genomic fragments spanning neighboring genes are analyzed, suggesting that important regulatory regions may be located at large distances from the genes they control or that their specific context may be important. Four Glasses of transcriptional regulators have been identified recently that have been shown to directly regulate Hox gene expression in the murine nervous system: retinoic acid receptors, Krox20, the Pbx/exd family, and the Hox genes themselves.