Polarity and Critical Micelle Concentration of Surfactants Support the Catalytic Efficiency of Nanogels during Glycoside Hydrolyses
Polarity and Critical Micelle Concentration of Surfactants Support the Catalytic Efficiency of Nanogels during Glycoside Hydrolyses
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DOI：
10.1021/acscatal.2c01432
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发表时间：
2022-07
期刊：
影响因子：
12.9
通讯作者：
B. Sharma;S. Striegler
中科院分区：
文献类型：
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作者：
B. Sharma;S. Striegler
在细乳液中由可聚合单体和配体开发大分子催化剂需要使用表面活性剂和疏水物以在聚合之前稳定液滴并在聚合之后增溶所获得的颗粒。为了阐明所选择的表面活性剂对合成的大分子催化剂的催化性能的贡献，进行了系统的研究。因此，性质，极性，和非离子表面活性剂共混物的临界胶束浓度，所得到的聚丙烯酸酯凝胶的大小，和它们的催化糖苷水解过程中的性能之间的相关性被证明。在pH 7的HEPES缓冲液中，观察到优化的半透明凝胶的催化效率高达0.35 min-1 M-1，催化熟练度高达1，300，000。此外，发现催化效率线性地反比于聚丙烯酸酯的流体动力学直径。在选定的表面活性剂共混物中合成的凝胶的临界胶束浓度不同超过2个数量级。研究结果强调了在微凝胶和纳米凝胶催化剂的开发过程中仔细选择表面活性剂的总体关键需求。
The development of macromolecular catalysts from polymerizable monomers and ligands in miniemulsions requires the use of surfactants and hydrophobes for the stabilization of droplets before polymerization and for the solubilization of the obtained particles thereafter. In order to elucidate the contributions of the chosen surfactants on the catalytic performance of the synthesized macromolecular catalysts, a systematic study was performed. Thereby, a correlation between nature, polarity, and critical micelle concentration of nonionic surfactant blends, the size of the resulting polyacrylate gels, and their performance during catalytic glycoside hydrolyses was demonstrated. A catalytic efficiency of up to 0.35 min–1M–1and a catalytic proficiency of up to 1,300,000 were observed for an optimized, translucent gel in HEPES buffer at pH 7. The catalytic efficiency was furthermore found to depend linearly inversely on the hydrodynamic diameters of the polyacrylates. The gels were synthesized in selected surfactant blends with critical micelle concentrations that are different by more than 2 orders of magnitude. The results of the study emphasize an overall critical need for a careful surfactant selection during development of micro- and nanogel catalysts.