Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid
Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid
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DOI：
10.1016/j.plefa.2017.03.008
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发表时间：
2017-05-01
影响因子：
3
通讯作者：
Lamarche, Benoit
中科院分区：
文献类型：
--
作者：
Allaire, Janie;Harris, William S.;Lamarche, Benoit
背景：最近的研究表明，二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 对心脏代谢危险因素具有明显的影响。 Omega-3 指数 (030，计算为红细胞 (RBC) 膜中 EPA 和 DHA 的比例，与冠心病和冠心病死亡率呈负相关。本研究的目的是比较补充 EPA 和 DHA 对患有腹部肥胖和亚临床炎症的男性和女性的 031 的影响。方法： 在一项双盲对照交叉研究中，48 名患有腹部肥胖和亚临床炎症的男性和 106 名女性被随机分为三个治疗阶段：1-2.7 克/天的 EPA、2-2.7 克/天的 DHA 和 3-3 克/天的玉米油（0 克 EPA + DHA）。所有补充剂均以 3 x 1 g 胶囊的形式提供，总计 3 g/天。 10周治疗 各阶段被九周的冲洗分开。在基线和每个阶段结束时评估红细胞膜脂肪酸组成和 031。使用混合模型进行重复测量来评估治疗之间 031 的差异。 结果：补充 DHA 后 031 的增加（与对照相比 + 5.6%，P < 0.0001）显着大于 EPA 后（与对照相比 + 3.3%，P < 0.0001； DHA 与 EPA，P < 0.0001）。与对照相比，DHA 补充量减少（-0.8%，P < 0.0001），而 EPA 增加（+ 2.5%，P < 0.0001）红细胞中二十二碳五烯酸 (DPA) 的比例（DHA 与 EPA，P < 0.0001）。女性的基线 031 高于男性（6.3% vs. 5.8%，P = 0.011）。 DHA 和 EPA 在增加 031 方面的差异在男性中往往高于女性（分别为 + 2.6% 和 + 2.2%，性别相互作用治疗的 P = 0.0537）。结论：补充高剂量 DHA 时 031 的增加比高剂量 EPA 更大，这与 DHA 调节心脏代谢危险因素的更大效力一致。程度 EPA 和 DHA 在增加 031 方面的这种差异与长期心血管风险有关，需要在未来进行研究。
Background: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (030, which is calculated as the proportion of EPA and DHA in red blood cell (RBC) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the 031 in men and women with abdominal obesity and subclinical inflammation.Methods: In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three-treatment phases: 1-2.7 g/d of EPA, 2-2.7 g/d of DHA, and 3-3 g/d of corn oil (0 g of EPA +DHA). All supplements were provided as 3 x 1 g capsules for a total of 3 g/d. The 10-week treatment phases were separated by nine-week washouts. RBC membrane fatty acid composition and 031 were assessed at baseline and the end of each phase. Differences in 031 between treatments were assessed using mixed models for repeated measures.Results: The increase in the 031 after supplementation with DHA (+ 5.6% compared with control, P < 0.0001) was significantly greater than after EPA (+ 3.3% compared with control, P < 0.0001; DHA vs. EPA, P < 0.0001). Compared to control, DHA supplementation decreased (-0.8%, P < 0.0001) while EPA increased (+ 2.5%, P < 0.0001) proportion of docosapentaenoic acid (DPA) in RBCs (DHA vs. EPA, P < 0.0001). The baseline 031 was higher in women than in men (6.3% vs. 5.8%, P = 0.011). The difference between DHA and EPA in increasing the 031 tended to be higher in men than in women (+ 2.6% vs. + 2.2% respectively, P for the treatment by sex interaction = 0.0537).Conclusions: The increase in the 031 is greater with high dose DHA supplementation than with high dose EPA, which is consistent with the greater potency of DHA to modulate cardiometabolic risk factors. The extent to which such differences between EPA and DHA in increasing the 031 relates to long-term cardiovascular risk needs to be investigated in the future.