Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89
Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89
复制标题
Borrelidins F-I，来自红树林来源的罗氏链霉菌 SCSIO ZJ89 的细胞毒性和细胞迁移抑制剂
DOI：
10.1016/j.bmc.2018.01.010
复制
发表时间：
2018-05-01
影响因子：
3.5
通讯作者：
Ju, Jianhua
中科院分区：
文献类型：
--
作者：
Sun, Jianbin;Shao, Junli;Ju, Jianhua
疏螺旋体素A（1）是由几种链霉菌产生的，在其生物活性支架内，乙烯腈部分是活性所必需的。本文报道了新发现的疏螺旋体素家族成员，疏螺旋体素F（2），疏螺旋体素G（3），疏螺旋体素H（4）和疏螺旋体素I（5）;所有这些都是从来源于红树林沉积物样品的罗氏链霉菌SCSIO ZJ 89中分离出来的。这些结构多样的代谢物使得许多新的结构-活性关系（SAR）得以鉴定，特别是关于C11-OH和C12-C15双键的不同构型，使用光谱方法确定了绝对构型。重要的是，发现疏螺旋体素H（4）在体外具有上级疏螺旋体素A（1）的治疗窗口，并且可以抑制癌细胞的迁移。(C)2018爱思唯尔有限公司版权所有。
Borrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods. Importantly, borrelidin H (4) was found to have a therapeutic window superior to that of borrelidin A (1) in vitro and could inhibit migration of cancer cells. (C) 2018 Elsevier Ltd. All rights reserved.