Strain- and genotype-specific differences in virulence of Paenibacillus larvae subsp larvae, a bacterial pathogen causing American foulbrood disease in honeybees
Strain- and genotype-specific differences in virulence of Paenibacillus larvae subsp larvae, a bacterial pathogen causing American foulbrood disease in honeybees
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DOI：
10.1128/aem.71.11.7551-7555.2005
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发表时间：
2005-11-01
影响因子：
4.4
通讯作者：
Fries, I
中科院分区：
文献类型：
--
作者：
Genersch, E;Ashiralieva, A;Fries, I
类芽孢杆菌幼虫亚种的毒力变异。幼虫是美国蜜蜂幼虫腐臭病的病原体，通过分析该病原体的 16 个田间分离株（属于先前鉴定的三种基因型）以及 P. larvae subsp. 的模式菌株（ATCC 9545）进行了研究。幼虫，进行暴露生物测定。我们证明了菌株特异性 50% 致死浓度在一个数量级内变化，并且病原体杀死 100% 受感染宿主 (LT100) 的时间差异与基因型相关。一种基因型杀死得相当快，平均 LT100 为感染后 7.8 +/- 1.7 天，而其他基因型则作用较慢，平均 LT(100) 为感染后 11.2 +/- 0.8 和 11.6 +/- 0.6 天。
Virulence variations of Paenibacillus larvae subsp. larvae, the causative agent of American foulbrood disease of honeybees, were investigated by analysis of 16 field isolates of this pathogen, belonging to three previously characterized genotypes, as well as the type strain (ATCC 9545) of P. larvae subsp. larvae, with exposure bioassays. We demonstrated that the strain-specific 50% lethal concentrations varied within an order of magnitude and that differences in amount of time for the pathogen to kill 100% of the infected hosts (LT100) correlated with genotype. One genotype killed rather quickly, with a mean LT100 of 7.8 +/- 1.7 days postinfection, while the other genotypes acted more slowly, with mean LT(100)s of 11.2 +/- 0.8 and 11.6 +/- 0.6 days postinfection.