Implant Porosity and the Foreign Body Response
Implant Porosity and the Foreign Body Response
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DOI：
10.1097/prs.0000000000003930
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发表时间：
2018-01-01
影响因子：
3.6
通讯作者：
Dumanian, Gregory A.
中科院分区：
文献类型：
--
作者：
Jordan, Sumanas W.;Fligor, Jennifer E.;Dumanian, Gregory A.
人工网片的生物相容性取决于最终激发最佳异物反应的一系列物理化学性质。异物反应的大小和性质直接影响到疝修补术的临床成功率，过少的瘢痕会导致腹股沟隆起或复发，过多的异物会引起网状皱纹和疼痛。此外，重要的是要考虑持续的异物反应和瘢痕重塑对随着时间推移的系膜组织结构的结合强度的影响。了解决定异物反应的关键因素，如植入物的孔隙度、表面积和细丝大小，对手术效果至关重要。新的可吸收材料引入了额外的变量，即异物本身溶解后异物反应的耐久性和持久性。在这篇综述中，我们讨论了关于异物反应的质量与植入物的物理属性相关的实验和临床文献，以努力揭开假体网片选择的神秘面纱。
The biocompatibility of prosthetic mesh is dependent on a number of physicochemical properties that ultimately incite an optimal foreign body response. The magnitude and character of the foreign body response directly affect the clinical success of the hernia repair, with too little scar resulting in bulge or hernia recurrence and too much scar causing mesh wrinkling and pain. Moreover, it is important to consider the effect of a sustained foreign body response and scar remodeling on the combined strength of the meshtissue construct over time. Understanding key elements that determine the foreign body response, such as implant porosity, surface area, and filament size, is critical to the performance of surgery. New absorbable materials introduce the additional variable of durability and persistence of the foreign body response after the foreign body itself has dissolved. In this review, we discuss the experimental and clinical literature relating the quality of the foreign body response to the physical attributes of implants in an effort to demystify prosthetic mesh selection.