Utilising multichannel intraluminal impedance for diagnosing GERD: a review.
Utilising multichannel intraluminal impedance for diagnosing GERD: a review.
复制标题
利用多通道腔内阻抗诊断 GERD：综述。
DOI：
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发表时间：
2007
影响因子：
2.6
通讯作者：
Joseph A. Murray
中科院分区：
文献类型：
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作者：
James L. Wise;Joseph A. Murray
胃食管反流的诊断有时具有挑战性，特别是当症状对大剂量酸抑制无反应时。随着新技术的出现，可以检测和量化非酸性或弱酸性反流。多通道腔内阻抗（MII）在10多年前被引入，作为一种反流检测工具越来越受欢迎。检测非酸性或弱酸性反流事件、噬气以及辨别燕子真正的反流事件的能力，可能使它成为比单独检测pH值更强大的工具。这是一个回顾的作用，因为它涉及到胃食管反流和相关疾病的诊断。对正常人和胃反流的研究表明，非酸性或弱酸性反流经常发生。已经发表了几项研究，将pH值与MII进行比较，记录了反流发作的类型和频率。pH电极不能检测大多数非酸性或弱酸性反流事件。MII显示非酸反流在未经治疗的胃反流患者中比在正常人群中更少见。与有更多气体型反流事件的正常受试者相比，胃食管反流受试者有更大程度的液体型反流事件。在治疗的胃反流患者和正常患者中，质子泵抑制剂似乎并没有减少反流的量，但使反流变为非酸性或弱酸性。最近发表了评估伴有MII的GERD的非典型症状的工作。
The diagnosis of gastroesophageal reflux is sometimes challenging, especially when symptoms are unresponsive to high-dose acid suppression. With the advent of new technology it is possible to detect and quantify nonacid or weakly acidic reflux. Multichannel intraluminal impedance (MII), introduced over 10 years ago, is gaining popularity as a reflux detection tool. The ability to detect nonacid or weakly acidic reflux events, aerophagia, and to discern true reflux events from swallows could make it more a powerful tool than pH detection alone. This is a review of the role of MII as it pertains to the diagnosis of GERD and related disorders. Studies done on normal subjects and in GERD reveal that nonacid or weakly acidic reflux occurs frequently. Several studies have been published that document types and frequency or reflux episodes comparing pH to MII. pH electrodes fail to detect the majority of nonacid or weakly acidic reflux events. MII has revealed nonacid reflux to be less common in untreated GERD subjects than in normal subjects. GERD subjects have greater degrees of liquid-type reflux events compared to normal subjects who have more gas-type reflux events. In treated GERD subjects and normal subjects, proton pump inhibitors do not seem to decrease the amount of reflux but render the reflux nonacid or weakly acidic in nature. Recently work evaluating atypical symptoms of GERD with MII has been published.