Smoking decreases the duration of life lived with and without cardiovascular disease: a life course analysis of the Framingham Heart Study
Smoking decreases the duration of life lived with and without cardiovascular disease: a life course analysis of the Framingham Heart Study
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DOI：
10.1016/j.ehj.2003.12.015
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发表时间：
2004-03-01
影响因子：
39.3
通讯作者：
Bonneux, L
中科院分区：
文献类型：
--
作者：
Al Mamun, A;Peeters, A;Bonneux, L
目的比较吸烟者和非吸烟者心血管疾病负担的终生风险和患病寿命。方法和结果我们构建了多状态生命表，描述了在原始弗雷明汉心脏研究中观察到的4723名吸烟者和非吸烟者的各种心血管疾病的转变。不吸烟者的寿命比吸烟者长8.66年（95% CI 7.61-9.63）（男性）和7.59年（95% CI 6.33-8.92）（女性），且无心血管疾病的寿命更长：男性为6.22年（95% CI 5.09-7.30），女性为4.93年（95% CI 3.54-6.29）。但不吸烟者一生中患心血管疾病的时间更长：男性为2.43年（95% CI 1.72-3.16），女性为2.66年（95% CI 1.87-3.38）。在70岁之前，吸烟者患心血管疾病的风险更高，但在整个生命周期中，男性不吸烟者患冠心病、心肌梗死、中风和充血性心力衰竭的风险更高，女性不吸烟者患冠心病和充血性心力衰竭的风险更高。结论吸烟通过缩短寿命降低心血管疾病的发生概率和持续时间。不吸烟者的寿命比吸烟者长许多年，不患心血管疾病的时间也更长，但在他们生命的最后，不吸烟者患心血管疾病的时间更长。(C) 2004年由Elsevier Ltd代表欧洲心脏病学会出版。
Aims To compare the burden of cardiovascular disease in terms of lifetime risk and life years lived with disease between smokers and non-smokers.Methods and results We constructed multi-state life tables describing transitions through various cardiovascular diseases for 4723 smokers and non-smokers observed during 20 biannual observations in the Original Framingham Heart Study. Non-smokers live 8.66 (95% CI 7.61-9.63) (men) and 7.59 (95% CI 6.33-8.92) (women) years longer than smokers and more years free of cardiovascular disease: 6.22 (95% CI 5.09-7.30) years for mates and 4.93 (95% CI 3.54-6.29) for females. But non-smokers spend more years with cardiovascular disease over the life course: 2.43 (95% CI 1.72-3.16) years for mates and 2.66 (95% CI 1.87-3.38) years for females. The risk of cardiovascular disease before age 70 is higher among smokers, but over the entire lifecourse mate non-smokers have higher risks of coronary heart disease, myocardial infarction, stroke and congestive heart failure, and female non-smokers have higher risks of coronary heart disease and congestive heart failure.Conclusion Smoking, by shortening life, decreases both the probability and duration of cardiovascular disease throughout the life course. Non-smokers live many years longer and longer free of cardiovascular disease than smokers, but at the end of their life non-smokers will have lived longer with cardiovascular disease. (C) 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.