Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters.
Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters.
复制标题
肿瘤促进剂刺激人多形核白细胞超氧阴离子自由基的产生。
DOI：
10.1016/0304-3835(81)90117-8
复制
发表时间：
1981
期刊：
影响因子：
9.7
通讯作者：
Troll,W
中科院分区：
文献类型：
--
作者：
Goldstein,BD;Witz,G;Amoruso,M;Stone,DS;Troll,W
摘要 比较了强效肿瘤促进剂佛波酯乙酸酯 (PMA) 以及活性较低的 PMA 类似物和非佛波酯肿瘤促进剂刺激人多形核白细胞 (PMN) 产生超氧阴离子自由基 (O 2• ) 的能力。发现 O 2• 产生速率与佛波酯的肿瘤促进活性相关，而不是其炎症活性。 Telocidin B 是比无活性的 PMA 更好的 O 2• 产生刺激剂。这些数据是根据 O 2• 和其他活性氧在肿瘤促进中的可能作用进行讨论的。
Abstract Comparison was made of the ability of the potent tumor promoter phorbol myristate acetate (PMA), as well as less active PMA analogs and non-phorbol ester tumor promoters, to stimulate superoxide anion radical (O 2• production by human polymorphonuclear leukocytes (PMN). The rate of O 2• production was found to correlate with the tumor-promoting activity of the phorbol esters as opposed to their inflammatory activity. Mezerein and telocidin B were slightly better stimulators of O 2• production than PMA. Acetic acid was inactive. These data are discussed in terms of a possible role for O 2• and other reactive oxygen species in tumor promotion.