DYNAMICS OF COATED MICROBUBBLES ADHERENT TO A WALL
DYNAMICS OF COATED MICROBUBBLES ADHERENT TO A WALL
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DOI：
10.1016/j.ultrasmedbio.2011.05.025
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发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Versluis, Michel
中科院分区：
文献类型：
--
作者：
Overvelde, Marlies;Garbin, Valeria;Versluis, Michel
超声分子成像是一种很有前途的非侵入性疾病特异性成像技术，例如，能够诊断血栓和炎症。选择性成像是通过使用配体功能化的超声造影剂微泡进行的，配体与目标分子特异性结合。在这里，我们调查在一个模型系统中，粘附在壁上的微泡的动力学的影响，特别是最大响应的频率，通过记录作为所施加的声压和频率的函数的单个微泡的径向响应。粘附性微泡的最大响应频率被发现是低于50%以上的无界流体中的气泡和低于30%以上的非粘附性气泡与壁接触。该变化是由气泡粘附到壁上引起的，因为没有发现仅由于靶向配体的存在对气泡动力学的影响。最大响应频率的偏移可能被证明对超声分子成像很重要，因为该应用将受益于声学成像方法，以区分粘附的微泡和自由循环的微泡。（电子邮件：m. utwente.nl）（C）2011年世界医学和生物学超声联合会。
Molecular imaging with ultrasound is a promising noninvasive technique for disease-specific imaging, enabling for instance, the diagnosis of thrombus and inflammation. Selective imaging is performed by using ultrasound contrast agent microbubbles functionalized with ligands, which bind specifically to the target molecules. Here, we investigate in a model system, the influence of adherence at a wall on the dynamics of the microbubbles, in particular, on the frequency of maximum response, by recording the radial response of individual microbubbles as a function of the applied acoustic pressure and frequency. The frequency of maximum response of adherent microbubbles was found to be over 50% lower than for bubbles in the unbounded fluid and over 30% lower than that of a nonadherent bubble in contact with the wall. The change is caused by adhesion of the bubbles to the wall as no influence was found due solely to the presence of the targeting ligands on the bubble dynamics. The shift in the frequency of maximum response may prove to be important for molecular imaging with ultrasound as this application would benefit from an acoustic imaging method to distinguish adherent microbubbles from freely circulating microbubbles. (E-mail: m.versluis@utwente.nl) (C) 2011 World Federation for Ultrasound in Medicine & Biology.