Sex Differences in the Brain's White Matter Microstructure during Development assessed using Advanced Diffusion MRI Models.
Sex Differences in the Brain's White Matter Microstructure during Development assessed using Advanced Diffusion MRI Models.
复制标题
使用高级扩散 MRI 模型评估发育过程中大脑白质微观结构的性别差异。
DOI：
10.1101/2024.02.02.578712
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Lawrence,KatherineE
中科院分区：
文献类型：
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作者：
Benavidez,SebastianM;Abaryan,Zvart;Kim,GaonS;Laltoo,Emily;McCracken,JamesT;Thompson,PaulM;Lawrence,KatherineE
发育过程中白色物质（WM）显微结构的典型性别差异还不完全清楚。在这里，我们评估了性别差异，在典型的大脑发育过程中，使用样本的神经典型的个人在一个广泛的发展年龄（N=239，年龄5-22岁）。我们使用传统的扩散加权MRI（dMRI）模型，扩散张量成像（DTI），和两个先进的dMRI模型，张量分布函数（TDF）和神经突方向弥散密度成像（NODDI），以评估WM的微观结构。WM微观结构表现出显着的，区域一致的性别差异在整个大脑在典型的发展。此外，TDF模型在检测性别差异方面最敏感。这些发现强调了在神经发育研究中考虑性别的重要性，并强调了先进的TDF模型的价值。
Typical sex differences in white matter (WM) microstructure during development are incompletely understood. Here we evaluated sex differences in WM microstructure during typical brain development using a sample of neurotypical individuals across a wide developmental age (N=239, aged 5-22 years). We used the conventional diffusion-weighted MRI (dMRI) model, diffusion tensor imaging (DTI), and two advanced dMRI models, the tensor distribution function (TDF) and neurite orientation dispersion density imaging (NODDI) to assess WM microstructure. WM microstructure exhibited significant, regionally consistent sex differences across the brain during typical development. Additionally, the TDF model was most sensitive in detecting sex differences. These findings highlight the importance of considering sex in neurodevelopmental research and underscore the value of the advanced TDF model.