Dynamical Characteristics of Wild-Type Mouse Spontaneous Pupillary Fluctuations
Dynamical Characteristics of Wild-Type Mouse Spontaneous Pupillary Fluctuations
复制标题
野生型小鼠瞳孔自发波动的动力学特征
DOI：
10.1109/embc46164.2021.9630747
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Aihara Kazuyuki
中科院分区：
文献类型：
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作者：
Sviridova Nina;Artoni Pietro;Fagiolini Michela;Hensch Takao K.;Aihara Kazuyuki
在人类和小鼠模型中自发瞳孔大小波动是一种无创测量数据，可用于神经发育谱系障碍的早期检测。虽然在这些应用研究中具有很高的价值，但瞳孔动力学和动态特性尚未得到充分的研究，尽管对它们的理解可能会导致发现新信息，而这些信息是传统方法无法轻易发现的。瞳孔测量动力学的特性，如决定论，先前已在健康受试者中进行了研究；然而，小鼠模型中瞳孔测量数据的动态特性，以及它们是否与人类受试者相似，在很大程度上仍然未知。因此，有必要对小鼠瞳孔动力学的动力学特性建立一个透彻的认识，并澄清其是否与人类相似。本文采用非线性时间序列分析方法，对115只野生型小鼠的动态瞳孔测量特性进行了研究。结果清楚地表明，在调查数据中有很强的潜在决定论。此外，估计了数据的轨迹发散率和可预测性。
Spontaneous pupil size fluctuations in humans and mouse models are noninvasively measured data that can be used for early detection of neurodevelopmental spectrum disorders. While highly valuable in such applied studies, pupillometry dynamics and dynamical characteristics have not been fully investigated, although their understanding may potentially lead to the discovery of new information, which cannot be readily uncovered by conventional methods. Properties of pupillometry dynamics, such as determinism, were previously investigated for healthy human subjects; however, the dynamical characteristics of pupillometry data in mouse models, and whether they are similar to those of human subjects, remain largely unknown. Therefore, it is necessary to establish a thorough understanding of the dynamical properties of mouse pupillometry dynamics and to clarify whether it is similar to that of humans. In this study, dynamical pupillometry characteristics from 115 wild-type mouse datasets were investigated by methods of nonlinear time series analysis. Results clearly demonstrated a strong underlying determinism in the investigated data. Additionally, the data’s trajectory divergence rate and predictability were estimated.