A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism
A Pilot Study on the Combination of Applied Behavior Analysis and Bumetanide Treatment for Children with Autism
复制标题
DOI：
10.1089/cap.2015.0045
复制
发表时间：
2015-09-01
影响因子：
1.9
通讯作者：
Jia, Feiyong
中科院分区：
文献类型：
--
作者：
Du, Lin;Shan, Ling;Jia, Feiyong
目的：本研究旨在探讨布美他尼联合应用行为分析（ABA）治疗自闭症儿童的疗效。方法：将60名根据国际疾病分类第十次修订（ICD-10）标准诊断为自闭症的儿童（平均年龄4.5岁）随机分为两组：单一治疗组（n=28）和联合治疗组（n=32）。联合治疗组接受ABA训练联合口服布美他尼（0.5 mg，每天两次）。单一治疗组仅接受 ABA 训练。使用自闭症行为检查表（ABC）和儿童自闭症评定量表（CARS）评估自闭症症状，而使用临床总体印象（CGI）测量疾病严重程度（SI）和整体改善（GI）。 ABC、CARS 和 CGI 的评估在治疗开始前和治疗后 3 个月进行。结果：在干预之前，两组之间的 ABC、CARS、SI 或 GI 得分没有发现统计学上的显着差异。 3 个月后，两组的 ABC、CARS 和 SI 总分均下降（p
Objective: The purpose of this study was to investigate the therapeutic effects of combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. Methods: Sixty children diagnosed with autism according to the International Classification of Diseases, Tenth Revision (ICD-10) criteria (mean age of 4.5 years) were randomly divided into two groups: A single treatment group (n=28) and a combined treatment group (n=32). The combined treatment group received ABA training combined with oral bumetanide (0.5 mg twice a day). The single treatment group received ABA training only. Autism symptoms were evaluated with the Autism Behavior Checklist (ABC) and the Childhood Autism Rating Scale (CARS), whereas severity of disease (SI) and global improvement (GI) were measured with the Clinical Global Impressions (CGI). Assessment of ABC, CARS, and CGI was performed immediately before and 3 months after initiation of the treatment(s). Results: Prior to intervention(s) no statistically significant differences in scores on the ABC, CARS, SI, or GI were found between the two groups. Total scores of the ABC, CARS, and SI were decreased in both groups after 3 months (p