Self-assembly and mineralization of peptide-amphiphile nanofibers
Self-assembly and mineralization of peptide-amphiphile nanofibers
复制标题
DOI：
10.1126/science.1063187
复制
发表时间：
2001-11-23
期刊：
影响因子：
56.9
通讯作者：
Stupp, SI
中科院分区：
文献类型：
--
作者：
Hartgerink, JD;Beniash, E;Stupp, SI
我们利用ph诱导的肽两亲体的自组装来制造纳米结构的纤维支架，使人联想到细胞外基质。这种肽两亲体的设计允许纳米纤维可逆交联，以增强或降低其结构完整性。交联后，纤维能够引导羟基磷灰石矿化形成复合材料，其中羟基磷灰石的晶体轴与纤维的长轴对齐。这种排列与骨中胶原原纤维和羟基磷灰石晶体之间的排列相同。
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly crosslinked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite material in which the crystallographic c axes of hydroxyapatite are aligned with the tong axes of the fibers. This alignment is the same as that observed between Collagen fibrils and hydroxyapatite crystals in bone.