Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism
Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism
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DOI：
10.1161/01.hyp.0000038478.59760.41
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发表时间：
2002-12-01
期刊：
影响因子：
8.3
通讯作者：
Veglio, F
中科院分区：
文献类型：
--
作者：
Mulatero, P;Rabbia, F;Veglio, F
原发性醛固酮增多症是一种可治疗且有可能治愈的继发性高血压。醛固酮/血浆肾素活性比（ARR）是常规筛选试验。降压治疗可干扰该参数的解释，但正确的洗脱期可能是有害的。我们研究了阿替洛尔、氨氯地平、多沙唑嗪、福辛普利和厄贝沙坦对230例疑似原发性醛固酮增多症患者ARR的影响。与对照相比，服用氨氯地平的患者ARR变化百分比为-17%+/-32；阿替洛尔,62% + / -82;doxazosin, -5% + / -26;fosinopril, -30% + / -24;厄贝沙坦-43%+/-27。阿替洛尔引起的ARR变化明显高于其他药物(P
Primary aldosteronism is a specifically treatable and potentially curable form of secondary hypertension. The aldosterone/plasma renin activity ratio (ARR) is routinely used as a screening test. Antihypertensive therapy can interfere with the interpretation of this parameter, but a correct washout period can be potentially harmful. We have investigated the effects of therapy with atenolol, amlodipine, doxazosin, fosinopril, and irbesartan on the ARR in a group of 230 patients with suspected primary aldosteronism. The percent change from control of ARR in patients taking amlodipine was -17%+/-32; atenolol, 62%+/-82; doxazosin, -5%+/-26; fosinopril, -30%+/-24; and irbesartan, -43%+/-27. The ARR change induced by atenolol was significantly higher compared with that induced by all other drugs (P