Association of NIDDM and hearing loss
Association of NIDDM and hearing loss
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DOI：
10.2337/diacare.21.9.1540
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发表时间：
1998-09-01
期刊：
影响因子：
16.2
通讯作者：
Wiley, TL
中科院分区：
文献类型：
--
作者：
Dalton, DS;Cruickshanks, KJ;Wiley, TL
目的-在一项基于大规模人群的研究中评估NIDDM与听力损失的相关性。研究设计和方法-在威斯康星州的比弗坝进行的基于人群的老龄化纵向研究的数据被用于这些分析。听力阈值由经培训的技术人员按照美国言语-语言-听力协会的规范进行纯音气导和骨导测听。听力损失被定义为频率500、1，000、2，000和4，000 Hz的纯音平均值高于较差耳朵的25分贝听力水平。糖尿病状态通过医生诊断的糖尿病的自我报告或检查时血糖或糖化血红蛋白水平升高来确定。结果-在3，571名研究参与者中，344名被归类为NIDDM。NIDDM受试者比非糖尿病受试者更容易发生听力损失（59 vs. 44%）。在对结果进行年龄调整后，这种差异没有统计学意义。在排除了与老年性耳聋不一致的听力损失模式的个体后，当控制潜在的混杂因素时，NIDDM与听力损失之间存在相关性（比值比[OR] 1.41，95%CI 1.05 - 1.88）。糖尿病持续时间或血糖控制与听力损失之间没有关联。与NIDDM但无肾病的患者相比，NIDDM合并肾病的患者更易发生听力损失（OR 2.28，95%CI 1.04 - 5.00）。
OBJECTIVE - To evaluate the association of NIDDM with hearing loss in a large population-based study RESEARCHDESIGN AND METHODS- Data from population-based longitudinal studies of aging conducted in Beaver Dam, Wisconsin, were used in these analyses. Hearing thresholds were determined by pure-tone air- and bone-conduction audiometry performed by trained technicians following American Speech-Language-Hearing Association specifications. Hearing loss was defined as the pure-tone average of the frequencies 500, 1,000, 2,000, and 4,000 Hz greater than 25 decibels hearing level in the worse ear. Diabetes status was determined by self-report of physician-diagnosed diabetes or by elevated glucose or glycated hemoglobin levels at examination.RESULTS - Of 3,571 study participants, 344 were classified as having NIDDM. Subjects with NIDDM were more likely to have a hearing loss than were subjects without diabetes (59 vs. 44%). After results were adjusted for age, this difference was not statistically significant. After individuals with hearing loss patterns inconsistent with presbycusis were excluded, there was an association between NIDDM and hearing loss when controlling for potential confounders (odds ratio [OR] 1.41, 95% CI 1.05-1.88). There was no association between duration of diabetes or glycemic control and hearing loss. Individuals with NIDDM and nephropathy were more likely to have a hearing loss than were those with NIDDM but no nephropathy (OR 2.28, 95% CI 1.04-5.00).CONCLUSIONS - These data are suggestive of a weak association between NIDDM and hearing loss.