An evaluation of indices for quantifying tuberculosis transmission using genotypes of pathogen isolates.
An evaluation of indices for quantifying tuberculosis transmission using genotypes of pathogen isolates.
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DOI：
10.1186/1471-2334-6-92
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发表时间：
2006-06-07
影响因子：
3.7
通讯作者：
Francis AR
中科院分区：
文献类型：
--
作者：
Tanaka MM;Phong R;Francis AR
传染病的研究通常是通过使用遗传标记来表征病原体的种群结构。一个尚未解决的问题是有效的量化传播的程度，使用遗传变异数据从这些病原体分离。重要的是，传播指数反映了传染性人口的增长，并说明了标记的突变率和采样的影响。也就是说，在响应这个增长率的同时，指数应该对样本量和突变率没有反应。我们使用模拟方法，同时考虑到突变和采样过程，以评估指标，旨在量化结核病的传播。根据上述标准，以前提出的指数通常表现不佳，最近提出的传输突变指数是部分例外。任何传播指标都需要考虑标记的突变和采样的影响。简单的指数不太可能反映基本过程的全部复杂性。
Infectious diseases are often studied by characterising the population structure of the pathogen using genetic markers. An unresolved problem is the effective quantification of the extent of transmission using genetic variation data from such pathogen isolates. It is important that transmission indices reflect the growth of the infectious population as well as account for the mutation rate of the marker and the effects of sampling. That is, while responding to this growth rate, indices should be unresponsive to the sample size and the mutation rate. We use simulation methods taking into account both the mutation and sampling processes to evaluate indices designed to quantify transmission of tuberculosis. Previously proposed indices generally perform inadequately according to the above criteria, with the partial exception of the recently proposed Transmission-Mutation Index. Any transmission index needs to take into account mutation of the marker and the effects of sampling. Simple indices are unlikely to capture the full complexity of the underlying processes.
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DOI：
10.1073/pnas.022618299
发表时间：
2002-02-05
影响因子：
11.1
作者：
Murray, M
通讯作者：
Murray, M
影响因子：
1.4
作者：
Rosenberg, NA;Tsolaki, AG;Tanaka, MM
通讯作者：
Tanaka, MM
影响因子：
5
作者：
Murray, M;Alland, D
通讯作者：
Alland, D
影响因子：
158.5
作者：
ALLAND, D;KALKUT, GE;BLOOM, BR
通讯作者：
BLOOM, BR
影响因子：
158.5
作者：
SMALL, PM;HOPEWELL, PC;SCHOOLNIK, GK
通讯作者：
SCHOOLNIK, GK