Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome.
Initial platelet serotonin (5-HT) transport kinetics predict nortriptyline treatment outcome.
复制标题
初始血小板血清素 (5-HT) 转运动力学可预测去甲替林治疗结果。
DOI：
10.1097/00004714-200304000-00006
复制
发表时间：
2003
影响因子：
2.9
通讯作者：
Johnson,MariaE
中科院分区：
文献类型：
--
作者：
Rausch,JeffreyL;Moeller,FrederickG;Johnson,MariaE
根据初始条件假设，药物反应可能由神经递质蛋白识别系统的不同初始状态决定。对24例抑郁症患者用去甲替林（75 mg）治疗3周前后的血小板5-羟色胺（5-HT）转运动力学作为抗抑郁反应的初始条件预测因子进行了研究。5-HT转运蛋白（5-HTT）的初始亲和力正确预测了71%的结果。治疗前亲和力常数（Km）与治疗3周后测定的亲和力常数（Kapp）相关（r= 0.61; p< 0.002）。有反应的患者有显着较高的初始Km治疗前和显着较高的Kapp治疗后。无应答者的初始Km显著低于24名对照。反应组间去甲替林血浆水平无统计学差异。这些结果与先前发表的两个观察结果一致，这表明5-HTT的初始亲和力以相同的方式预测对氟伏沙明或氟西汀的反应。由于所有三种药物都增加了5-HTT的表观亲和力，因此似乎更好的反应与治疗前初始亲和力已经较高的那些病例有关。
According to the hypothesis of initial conditions, drug response may be determined by different initial states of neurotransmitter protein recognition systems. Platelet serotonin (5-HT) transport kinetics were studied as initial-conditions predictors of antidepressant response in 24 depressed patients before and after 3 weeks of treatment with nortriptyline (75 mg). The initial affinity of the 5-HT transporter (5-HTT) correctly predicted 71% of the outcome. The pretreatment affinity constant (K m) correlated (r= 0.61; p< 0.002) with that measured after 3 weeks of treatment (Kapp). Responding patients had a significantly higher initial K m before treatment and a significantly higher Kapp after treatment. Nonresponders had an initial K m significantly lower than that of 24 controls. Nortriptyline plasma levels were not statistically different between response groups. These results are consistent with two previously published observations, which indicate that the initial affinity of the 5-HTT predicted response to fluvoxamine or fluoxetine in the same way. Insofar as all three drugs increase the apparent affinity of the 5-HTT, it appears that a better response is related to those cases where the initial affinity is already higher before treatment.