Depression after stroke and risk of mortality: a systematic review and meta-analysis.
Depression after stroke and risk of mortality: a systematic review and meta-analysis.
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DOI：
10.1155/2013/862978
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发表时间：
2013
影响因子：
1.5
通讯作者：
Clerici M
中科院分区：
文献类型：
--
作者：
Bartoli F;Lillia N;Lax A;Crocamo C;Mantero V;Carrà G;Agostoni E;Clerici M
背景资料。中风后的抑郁可能会对功能恢复和长期结果产生巨大的负担。目标。评估卒中后抑郁与随后死亡率之间的关系。方法：研究方法。使用PubMed和Web of Science数据库对文章进行系统搜索。优势比(ORs)和风险比(HRs)被用作基于随机效应模型的合并分析的关联测量。结果。13项研究，涉及59,598名中风患者(6,052名患有抑郁症，53,546名不患有抑郁症)，拥有适合荟萃分析的数据。卒中后抑郁患者随访时死亡率的合并OR为1.22(1.02-1.47)。分组分析强调，只有中期随访(2-5年)的研究显示抑郁和死亡风险之间存在统计上的显著关联。有四项研究的数据适用于进一步分析合并的HR。荟萃分析显示，中风后抑郁症患者的死亡率比为1.52(1.02-2.26)。结论。尽管有一些局限性，但这篇论文证实了抑郁症对卒中后死亡率的潜在作用。卒中后抑郁与死亡率的关系似乎与随访时间有关。需要进一步的研究来澄清中风后抑郁和死亡率之间的联系的性质。
Background. Depression after stroke may have great burden on the likelihood of functional recovery and long-term outcomes. Objective. To estimate the association between depression after stroke and subsequent mortality. Methods. A systematic search of articles using PubMed and Web of Science databases was performed. Odds ratios (ORs) and hazard ratios (HRs) were used as association measures for pooled analyses, based on random-effects models. Results. Thirteen studies, involving 59,598 subjects suffering from stroke (6,052 with and 53,546 without depression), had data suitable for meta-analysis. The pooled OR for mortality at followup in people suffering from depression after stroke was 1.22 (1.02–1.47). Subgroups analyses highlighted that only studies with medium-term followup (2–5 years) showed a statistically significant association between depression and risk of death. Four studies had data suitable for further analysis of pooled HR. The meta-analysis revealed a HR for mortality of 1.52 (1.02–2.26) among people with depression after stroke. Conclusions. Despite some limitations, this paper confirms the potential role of depression on post stroke mortality. The relationship between depression and mortality after stroke seems to be related to the followup duration. Further research is needed to clarify the nature of the association between depression after stroke and mortality.