PRODUCTION OF TRACHEOBRONCHITIS IN VOLUNTEERS WITH RHINOVIRUS IN A SMALL-PRACTICLE AEROSOL
PRODUCTION OF TRACHEOBRONCHITIS IN VOLUNTEERS WITH RHINOVIRUS IN A SMALL-PRACTICLE AEROSOL
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DOI：
10.1093/oxfordjournals.aje.a120501
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发表时间：
1965-01-01
影响因子：
5
通讯作者：
KNIGHT, V
中科院分区：
文献类型：
--
作者：
CATE, TR;COUCH, RB;KNIGHT, V
吸入16至66 TCID 50的鼻病毒NIH 1734包含在小颗粒（直径0.2至3.0微米）气溶胶中，导致8名无抗体（< 1/2）志愿者感染和患病。气管支气管炎的临床表现很突出，可能代表易感气管支气管部位的感染和损伤。这与先前研究的志愿者鼻咽接种后通常出现的鼻炎综合征形成对比。用血清灭活病毒对6名志愿者进行鼻咽接种，未产生疾病或感染。
Inhalation of 16 to 66 TCID50 of rhinovirus NIH 1734 contained in a small-particle (0.2 to 3.0 microns in diameter) aerosol resulted in infection and illness in each of 8 antibody-free (< 1 in 2) volunteers. There was a prominent clinical picture of tracheobronchitis which presumably represented infection and injury of susceptible tracheo-bronchial sites. This was in contrast to the coryzal syndrome which usually followed nasopharyngeal inoculation of previously studied volunteers. Nasopharyngeal inoculation of 6 volunteers with serum-inactivated virus produced no illness or infection.