Modulation of prolactin release by altered levels of thyroid hormones.
Modulation of prolactin release by altered levels of thyroid hormones.
复制标题
通过改变甲状腺激素水平来调节催乳素的释放。
DOI：
10.1016/0026-0495(74)90006-7
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
T. Yamaji
中科院分区：
文献类型：
--
作者：
T. Yamaji
为了描述甲状腺激素对催乳素释放的影响，通过异源人催乳素放射免疫测定法测定了甲状腺激素水平正常和改变的受试者给予合成促甲状腺激素释放激素（TRH）后的血清催乳素浓度。在16名男性和19名女性对照受试者中，静脉注射TRH引起催乳素水平的明确升高，在注射后15分钟达到峰值。催乳素的这种反应在所有10名未经治疗的甲亢患者中明显减弱，但在治疗后8名受试者中恢复。相反，TRH介导的催乳素释放在大多数原发性甲状腺功能减退症病例中增强。这些患者的甲状腺激素替代导致催乳素对TRH的反应降低。另一方面，用三碘甲状腺原氨酸治疗6名甲状腺功能正常的受试者，明确抑制了催乳素的释放。这些结果表明，甲状腺激素本身是负责钝化催乳素分泌TRH管理的反应。
In an attempt to delineate the effect of thyroid hormones on prolactin release, serum concentrations of prolactin in response to synthetic thyrotropin-releasing hormone (TRH) administration in subjects with normal and altered levels of thyroid hormones were determined by a heterologous radioimmunoassay for human prolactin. In 16 male and 19 female control subjects, an intravenous administration of TRH elicited a definite elevation in prolactin levels having a peak at 15 min after injection. This response of prolactin was markedly attenuated in all of the ten untreated hyperthyroid patients but was restored in eight subjects after the treatment. In contrast, TRH-mediated prolactin release was enhanced in most cases of primary hypothyroidism. Replacement of thyroid hormones in these patients resulted in a decrease in prolactin response to TRH. Treatment of six euthyroid subjects with triiodothyronine, on the other hand, unequivocally suppressed the release of prolactin. These results suggest that thyroid hormones per se are responsible for the blunted response of prolactin secretion to TRH administration.