Macrophages associated with tumors as potential targets and therapeutic intermediates.
Macrophages associated with tumors as potential targets and therapeutic intermediates.
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DOI：
10.2217/nnm.14.13
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Wei X
中科院分区：
文献类型：
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作者：
Vinogradov S;Warren G;Wei X
肿瘤相关巨噬细胞（TAM）约占肿瘤质量的50%。TAM显示通过抑制免疫活性细胞、诱导新血管形成和支持癌症干细胞来促进肿瘤生长。TAM在肿瘤块中保持移动性，这可以潜在地用于纳米载体的更好的肿瘤内生物分布和有效的肿瘤生长抑制。由于TAM的重要性，它们正日益成为新治疗方法的主要靶标。在这篇综述中，我们比较了巨噬细胞和TAM的功能，是必要的TAM导向治疗，并说明纳米医学的优势，相关的优先捕获纳米载体的Mφ在药物输送过程中。我们讨论了最近在重新编程或抑制TAM的肿瘤保护特性方面的努力，以及通过与巨噬细胞相关的纳米药物递送相结合来提高常规化疗疗效的潜在策略。
Tumor-associated macrophages (TAMs) form approximately 50% of tumor mass. TAMs were shown to promote tumor growth by suppressing immunocompetent cells, inducing neovascularization and supporting cancer stem cells. TAMs retain mobility in tumor mass, which can potentially be employed for better intratumoral biodistribution of nanocarriers and effective tumor growth inhibition. Due to the importance of TAMs, they are increasingly becoming principal targets of novel therapeutic approaches. In this review, we compare features of macrophages and TAMs that are essential for TAM-directed therapies, and illustrate the advantages of nanomedicine that are related to the preferential capture of nanocarriers by Mφ in the process of drug delivery. We discuss recent efforts in reprogramming or inhibiting tumor-protecting properties of TAMs, and potential strategies to increase efficacy of conventional chemotherapy by combining with macrophage-associated delivery of nanodrugs.